摘要
目的探讨多发梗死性痴呆(MID)大鼠的行为学特征及针刺的疗效。方法采用栓子注入法制作多发梗死性痴呆模型,分为模型组、针刺组和非穴组,并设正常组和假手术组。应用Morris水迷宫观测各组大鼠认知功能的变化。结果在隐蔽平台试验中针刺组逃避潜伏期较模型组及非穴组明显缩短(F4,68=13.96,P<0.05);与模型组[(15.21±2.53)s]及非穴组[(15.72±3.46)s]比较,针刺组原平台象限的停留时间[(21.01±1.55)s]明显延长(P<0.05);在反向试验中,针刺组逃避潜伏期亦较模型组及非穴组明显缩短(F4,68=8.95,P<0.05)。结论针刺治疗不仅可显著改善多发梗死性痴呆大鼠的空间记忆能力,而且能够提高动物的思维能力和分析判断能力,对痴呆大鼠的整个认知功能均有改善作用。
Objective To explore the therapeutic effect of acupuncture on rat of multi-infarct dementia （MID） by observation of the behavioral features. Methods The multi-infarct dementia model was made by injecting emboli into the internal carotid artery. Of them 43 proved dementia by Morris water maze were allocated to 3 groups： model, acup and sham-acup, meanwhile 30 normal and sham-operated rats were used as control. Morris water maze test was employed to assess spatial memory ability. Results In the hidden platform trial, acupuncture group showed significant decrease in escape latency compared to impaired and placebo-acupuncture rats（ F 4,68 = 13.96, P〈0. 05）. Acupuncture group（21.01 ± 1.55） spent significantly more time（ P〈0.05 ） in the training quadrant where the platform was previously located than impaired（ 15.21 ± 2.53 ）and placeboacupuncture groups（ 15.72 ± 3.46）, which visited all quadrants equally during 60s of probe trial. Reversal trial revealed that acupuncture group spent markedly less time to find the platform than impaired and placebo - acupuncture groups（ F 4,68 =-8.95, P 〈 0.05 ）. Conclusion The present results showed that acupuncture exerted a protective effect on cognitive impairment induced by cerebral multi-infarction in rats.
出处
《中国行为医学科学》
CSCD
2005年第12期1060-1062,共3页
Chinese Journal of Behavioral Medical Science
基金
国家自然科学基金资助项目(30472242)
天津市自然科学基金资助项目(033606811)
