摘要
目的探讨血脑利钠肽和ADH变化在急性颅脑外伤中的意义。方法对1996年1月～1997年8月收治的72例急性颅脑外伤（ACI）患者血中脑利钠肽（BNP）、抗利尿激素（ADH）含量进行监测，并对GCS≤8分病例行促甲状腺素释放激素（TRH）刺激试验。结果ACI患者血BNP浓度明显降低，血ADH浓度明显增高，其改变程度与脑外伤程度、脑实质细胞损害程度及脑伤预后密切相关。结论ACI导致下丘脑垂体功能障碍引起ADH分泌增加，促使机体特别是脑组织的水钠潴留是影响脑伤预后的重要因素。
Objective In order to elucidate the clinical significance of changes of blood BNP, ADH levels in acute craniocerebral injury.,Methods The changes of brain natriuretic pepitide (BNP), antidiuretic hormone (ADH) were observed in 72 patients with acute craniocerebral injury (ACI). And TRH provocative test was observed in patients with ACI (GCS ≤8). Results In ACI patients, the blood BNP concentration was statisticallylower than those of controls, the ADH levels was statistically higher than those of controls. There were correlation between the BNP, ADH levels were strongly correlated with and GCS, mass of lesion, and prognosis. ConclusionThe levels of ADH indicate the outcome of the water - saline preference in brain as the result of the hypothalamic - hypophysial system injury. TRH might inhibit water - saline preference by antagonizing the increase of ADH, and indicate a favourable outcome.
出处
《上海第二医科大学学报》
CSCD
1999年第1期38-40,55,共4页
Acta Universitatis Medicinalis Secondae Shanghai
