摘要
目的:对热毒宁治疗上呼吸道感染的临床疗效研究进行分析,并对其疗效做出客观的评价。方法:检索万方数据库及中国知网(CHKI)1998年1月～2009年6月发表的关于热毒宁治疗上呼吸道感染的随机对照临床试验,运用Jadad量表评价纳入文献的方法学质量,用RevMan4.2软件进行Meta分析。临床评价指标包括治疗总有效率、儿童组有效率、退热时间和咽痛消除时间。结果:符合纳入标准的有11篇文献。热毒宁(总有效率)的效应值(实验组与对照组疗效的比)(OR=5.10,95%CI=3.07,7.14);儿童组有效率对效应值(OR=4.25;95%CI=2.68,6.73;P<0.00001);退热时间的效应值(WMD=-0.78;95%CI=-0.86,-0.69;P<0.00001);咽痛消除时间的效应值(WMD=-1.01;95%CI=-1.10,-0.91;P<0.00001)。结论:初步认为热毒宁治疗上呼吸道感染有较确切的疗效。但由选择的文献范围较小,所纳入文献研究质量较低,可能存在发表性偏倚等因素的影响,尚需进一步论证。
Objective： To analyze and evaluate the efficacy of reduning injection in the treatment of upper respiratory tract infections. Methods：The literatures about random-control clinical trials on reduning injection in the treatment of upper respiratory tract infections were retrieved through Wangfang Database and CHKI from 1998 to 6, 2009, the methodological quality of inclusive trials were assessed by Jadad scale, and a meta-aualysis of the literatures was conducted by Rev- Man 4.2 software. The treatment of clinical evaluation indicators included total efficiency, duration of eliminative fever heat and sore throat. Results： 11 RCT were included. The synthesized efficacies of reduning injection total efficiency were OR = 5.10, 95% CI = 3.07, 7.14 （P 〈 0. 00001 ） ; children groups＇ total efficiencies were OR = 4.25, 95% CI = 2.68,6.73 （P 〈 0.00001 ） ; duration of the eliminative fever heat was WMD = - 0.78, 95 %, CI = - 0.86, - 0.69 （ P 〈 0. 00001 ） ; and duration of the eliminative sore throat was WMD = - 1.01, 95% CI = - 1.10, - 0.91 （ P 〈 0.00001 ）. Conclusion： The analaysis initially proved that reduning injection had its positive efficacy on upper respiratory tract infections. But be- cause of the limited and low quality literatures and published bias, the above conclusion needs its further study.
出处
《药物流行病学杂志》
CAS
2010年第6期314-319,共6页
Chinese Journal of Pharmacoepidemiology
关键词
热毒宁
上呼吸道感染
META分析
Reduning injection
Upper respiratory tract infection
Meta-analysis
