摘要
为了研究T淋巴细胞正群和HLA－DR变化与Alzheimer’s病（AD）病情的关系。采用荧光素标记的单抗直接标记，流式细胞仪对20例轻度AD痴呆和18例重度AD痴呆进行T淋巴细胞亚群和外局单核细胞HLA－DR抗原测定。结果发现：1．CD、CDT细胞在轻度AD组中均路下降，在重度AD组中均升高，但都无显著性差异（P＞0．05）；各组的CD／CD比值均在正常范围之内。2．HLA－DR抗原在轻、重度AD组中均升高，两组与对照组比较均有显著性差异（P＜0．05）。以上结果说明：T淋巴细胞亚群变化与AD病情的联系不明显，应慎重地对其细胞免疫功能进行评价；HLA－DR抗原变化与AD病情变化有一定的联系。
In this study we investigated immune-associated antigens of peripheral lymphocytes from patiente with Alzheimer's disease(AD). The result showed that in both mild and moderately severe stage of the disease a slight decrease in the CD and CD , and a slight increase in the CD and CD , however HLA-DR marker was significantly elevated in both mild and moderately severe stage. Marked changes support the hypothesis of a peripheral immune reaction in AD which may be correlated with the clinical stage of the disease.
出处
《脑与神经疾病杂志》
1999年第1期8-9,共2页
Journal of Brain and Nervous Diseases
