摘要
肝癌多药耐药的产生是多基因、多因素、多途径、多步骤综合作用的复杂过程,因此研究引起肝癌多药耐药的相关因素、作用机制及逆转MDR,提高肝癌化疗效果成为目前肝癌研究的热点,但不同的肝癌耐药细胞株有不同的多药耐药基因表型,如何针对不同的基因表型来逆转肝癌的多药耐药,是临床治疗肝癌需要面对的一个问题。
Multidrug resistance(MDR) of primary hepatic carcinoma is the multiplicity process of polygene,multiple factor and synthetic action.Research of MDR factor,mechanism,retroconversion and increase of chemotherapy is investigative warm spot currently.Different hepatoma cell line has dissimilar phenotype of multidrug resistance gene.How to aim directly at dissimilar gene phenotype to deteriorate MDR is fronting problem to heal primary hepatic carcinoma.
出处
《现代生物医学进展》
CAS
2010年第8期1586-1588,共3页
Progress in Modern Biomedicine
关键词
肝癌
多药耐药
化疗
hepatoma
multidrug resistance
chemotherapy