摘要
目的评价原发性肝细胞癌(HCC)动脉内栓塞化疗(TACE)后CT形态学与生存率的相关性。资料与方法65例(病理诊断17例,临床诊断48例)HCC患者进行了264次TACE,药物为吡柔比星50mg/m2、艾恒/顺铂50mg/m2,碘化油5～20ml和明胶海绵颗粒。肝脏和肿瘤体积用体积测量软件获得,碘化油沉积情况在治疗后3～4周随访CT评价。结果肿瘤体积<200ml(P<0.001)、肿瘤与肝脏体积的比值<5%(P<0.001)、碘化油完全沉积(≥75%)(P<0.001)的患者生存率明显提高,弥漫性生长方式的肿瘤(P<0.001)、存在9个以上病灶(P<0.001)和病变累及三个肝段以上的患者生存率较差。结论原发性HCCTACE后CT形态学评价与生存率有密切的相关性,对临床治疗起着重要的指导作用。
Objective To evaluate the correlation between computed tomography （CT） morphology and survival rate in patients treated with transarterial chemoembolization （TACE） for hepatocellular carcinoma （HCC）. Materials and Methods Sixty-five patients with HCC （17 proved by pathology,48 proved by clinical data） underwent 264 TACE procedures with 50 mg/m2 doxorubicin hydrochloride,50 mg/m2 cisplatin,5-20 ml iodized oil,and gelatin sponge partical. The volume of liver and tumor were measured using CT software.Iodized oil retention was estimated on CT images 3-4 weeks after TACE. Results The survival rate was obviously increased in patients with the following conditions：the tumor volume 200 ml,tumor volume/liver volume 5% and complete（≥75% volume） iodized oil retention. While the conditions which would decrease the survival rate included diffuse tumor growth pattern,presence of more than nine lesions and more than three segements involved. Conclusion After TACE treatment,CT morphology has strong correlation with survival rate in patients with HCC. CT features play great roles in guiding clinical therapy.
出处
《临床放射学杂志》
CSCD
北大核心
2010年第5期669-673,共5页
Journal of Clinical Radiology
关键词
原发性肝细胞肝癌
动脉内化疗栓塞
体层摄影术
X线计算机
生存率
相关性
Hepatocellular Carcinoma （HCC） Transarterial Chemoembolization （TACE） Tomography
X-ray computed Survival Associativity
