摘要
目的探讨肝动脉化疗栓塞术对肝癌患者甲胎蛋白（AFP）的影响及对预后判断的意义。方法通过双抗体夹心两步法对96例肝癌患者治疗前1周内、治疗后3—4周及治疗后7～8周的血清进行AFP测定。结果患者术前血清AFP值为（800．52±190．34）ng／ml，术后3～4周AFP值为（656．02-,c313．19）ng／ml，与术前比较稍有下降，但差异无统计学意义（P=0．118）；术后7—8周AFP值为（324．68±104．36）ng／ml，与术前比较有明显下降（P〈0．05）。患者术后随访平均存活时间250d，最短术后生存时间34d。结论AFP作为经导管肝动脉化疗栓塞术术后评定疗效的中长期指标比作为术后3—4周短期观察指标更合适。
Objective To investigate the effect of transcatheter hepatic arterial chemoembolization（TACE） on alpha-fetopro- tein（AFP） in patients with advanced hepatocellular carcinoma（ HCC）, and its prognostic significance. Methods Ninety-six pa- tients with HCC were assigned to receive TACE. The AFP were determined at 1 week before treatment, 3 - 4 weeks and 7 - 8 weeks after treatment. Results The changes of plasma AFP between the preoperation and 3 -4 weeks postoperation were not significant （P 〉 0. 05 ）, while the plasma AFP was delevated in the 7 -8 weeks compared with preoperation （P 〈 0. 05 ）. Conclu- sion AFP is more suitable as a long-term indicator than a 3 -4 weeks short-term indicator in evaluating efficacy for TACE.
出处
《临床医学》
CAS
2013年第12期4-6,共3页
Clinical Medicine
关键词
甲胎蛋白
动脉内化疗栓塞
原发性肝癌
Alpha-fetoprotein
Arterial chemoembolization
Hepatocellular carcinoma
