摘要
目的探讨心脏再同步治疗(CRT)1个月、3个月对慢性心力衰竭患者血清细胞因子水平的影响及其与左室射血分数(LVEF)的关系。方法入选心功能Ⅲ～Ⅳ级的患者30例,分为CRT组15例,对照组15例。两组于治疗前、治疗后1个月及3个月分别测定肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)浓度,超声测量LVEF。结果CRT组治疗3个月后TNF-α、IL-6浓度与治疗前相比明显下降。治疗后1个月及3个月,CRT组LVEF均较治疗前明显改善。细胞因子(TNF-α、IL-6)浓度与LVEF呈显著负相关。结论CRT治疗3个月后心功能改善的同时细胞因子浓度降低,提示血清TNF-α、IL-6浓度可作为慢性心力衰竭患者心功能的预测指标。
Objective To investigate the changes of serum cytokines in chronic heart failure （CHF） patients who received cardiac resynchronization therapy for 1 and 3 months and its relationship with left ventricular ejection fraction （LVEF）.Methods Thirty CHF patients with New York Heart Association （NYHA） classⅢor Ⅳwere selected. Fifteen patients received biventricular pacing therapy （CRT group） and the other 15 patients received optimal medical therapy （control group）. The LVEF and serum levels of TNF-α and IL-6 were determined before treatment,at 1,3 months after treatment respectively.Results The serum TNF-α and IL-6 concentrations were decreased significantly after 3 months of CRT treatment,and LVEF was improved remarkably after 1 and 3 months of CRT treatment. The serum cytokines （TNF-α and IL-6） level had a significant negative correlation with LVEF. Conclusion After 3 months of CRT treatment,the heart function is improved,and serum cytokines（TNF-α,IL-6） concentrations are decreased. It indicates that serum level of TNF-α and IL-6 may have predictive value for the heart function of patients with CHF.
出处
《中华老年多器官疾病杂志》
2010年第1期41-43,共3页
Chinese Journal of Multiple Organ Diseases in the Elderly
关键词
心力衰竭
细胞因子类
心脏再同步治疗
heart failure
cytokines
cardiac resynchronization therapy
