摘要
目的 观察老年2型糖尿病患者颈动脉病变与胰岛素抵抗之间的关系. 方法 老年2型糖尿病患者63例,分为糖化血红蛋白≤7.0％组30例和糖化血红蛋白＞7.0％组33例,另选取健康者30例为对照组.测定空腹血糖、空腹胰岛素及糖化血红蛋白.超声测量颈动脉内中膜厚度（IMT）,记录斑块数目,计算胰岛素抵抗指数. 结果 糖化血红蛋白≤7.0％组和糖化血红蛋白＞7.0％组的IMT、平均斑块数及颈动脉斑块发生率均高于对照组（均P＜0.05）；糖化血红蛋白≤7.0％组和糖化血红蛋白＞7.0％组的空腹胰岛素、糖化血红蛋白及HOMA-IR均较对照组增高（分别为P＜0.05和P＜0.01）；糖化血红蛋白＞7.0％组空腹胰岛素（13.6±2.0）mU/L、糖化血红蛋白（8.2±0.6）％及HOMA-IR（6.1±0.5）均较糖化血红蛋白≤7.0％组[分别为（9.7±2.1） mU/L、（6.5±0.4）％、3.5±0.4）]增高,差异有统计学意义（均P＜0.05）；Pearson相关分析结果显示,IMT与糖化血红蛋白≤7.0％组和糖化血红蛋白＞7.0％组的空腹血糖、胰岛素抵抗指数呈正相关（r值分别为0.62、0.46,均P＜0.05）. 结论 老年2型糖尿病患者颈动脉病变与胰岛素抵抗间呈正相关.
Objective To study the relationship between insulin resistance and carotid atherosclerosis in elderly patients with type 2 diabetes.Methods A total of 63 elderly patients with type 2 diabetes were divided into 2 groups：group A （HbA1c≤7%,n=30）,group B （HbA1c〉7%,n=33）; and 30 healthy people were as controls.Fasting blood sugar（FBS）,fasting insulin （FINS）,glycated hemoglobin （HbA1c） and carotid intima-media thickness （IMT） were measured,atherosclerotic plaques were counted,and insulin resistance was calculated by homeostatic model assessment （HOMA-IR）.Results The IMT,number of atherosclerotic plaques and incidence of carotid atherosclerosis were all higher in the two diabetic groups than in controls （P〈0.05）.The levels of FINS,HbA1c and HOMA-IR were all higher in group A and group B than in controls （P〈0.05 and P〈0.01）,which had a significant difference between group A and group B [（9.7± 2.1）mU/L vs.（13.6±2.0） mU/L; （6.5±0.4）% vs.（8.2±0.6）%; （3.5±0.4） vs.（6.1±0.5）; all P〈0.05].Pearson correlation analysis showed that IMT was positively correlated with FBS and HOMA-IR in group A and group B （r=0.62 and r=0.46,respectively,P〈0.05）.Conclusions There is a positive correlation between insulin resistance and carotid atherosclerosis in elderly patients with type 2 diabetes.
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2013年第5期504-506,共3页
Chinese Journal of Geriatrics
关键词
糖尿病
2型
动脉粥样硬化
胰岛素抗药性
Diabetes mellitus, type 2
Atherosclerosis
Insulin resistance
