摘要
目的探讨食管小细胞癌临床病理特征及免疫组化表达。方法收集48例食管小细胞癌,分析临床病理资料,每例均采用SP法做五项免疫组化标记,分别为NSE(神经元特异性烯醇化酶),Syn(突触蛋白),CgA(嗜鉻素A),CK(细胞角蛋白),LCA(白细胞共同抗原)。结果根据镜下形态,食管小细胞癌分为单纯小细胞型,中间细胞型,混合细胞型三种类型。免疫组化染色NSE,Syn,CgA,阳性率分别为93.7%,95.8%,79.2%。结论食管小细胞癌是一种高度恶性神经内分泌肿瘤,确诊主要依据病理组织学检查,免疫组化合理应用,NSE,Syn,CgA等两种以上阳性表达是食管小细胞癌的阳性指标,对诊断有确定性意义。
Objective To study the clinicpathological and immunohistochemical characteristics of small cell carcinoma（SCC） of esophagus.Methods The clinicpathological data of 48 patients were analyzed.The expressions of NSE、Syn、CgA、CK and LcA were detected by immunochemistry.Results According to the cancer cell type,these cases were classified into small cell type,middle cell type and mixed cell type.Immunohistochemically,45（93.7%）,46（95.8%）,38（79.2%） cases showed positive for NSE,Syn and CgA respectively.Conclusion Small cell carcinoma of the esophagus is a highly malignant neuroendocrine tumor.These results suggested NSE,CgA and Syn are useful and sensitive markers.
出处
《医药论坛杂志》
2010年第8期33-35,共3页
Journal of Medical Forum
关键词
食管癌
小细胞癌
免疫组化
Esophagus
Small cell carcinoma
Immunohistochemisty
