摘要
目的 探讨血浆中５羟色胺（５ＨＴ） 和５羟吲哚乙酸（５ＨＩＡＡ） 与妊高征发病的关系。 方法 采用高效液相色谱—电化学检测法测定正常妊娠各期孕妇组及妊高征组血浆中５ＨＴ和５ＨＩＡＡ含量。 结果 正常妊娠各期孕妇组血浆中５ＨＴ含量无显著差异；妊高征组血浆中５ＨＴ含量（７０－４４ ±２８－６９ μｇ／Ｌ）明显高于正常晚孕组（２４－９６±６－５７ μｇ／Ｌ）（ Ｐ＜ ０．０１） ；妊高征组血浆中５ＨＩＡＡ 含量（４－１１±２．３０ μｇ／Ｌ） 较正常晚孕组（７－８７ ±１．７５ μｇ／Ｌ） 明显降低，Ｐ＜ ０．０１。 结论 孕妇血浆中５ＨＴ含量变化可能与妊高征血管收缩的病理过程有关。
Objective To provide evidence for the hypothesis that the involvement of serotonin(5 HT) and 5 hydroxyindole acetate(5 HIAA) takes part in the pathogenesis of pregnancy induced hypertension(PIH). Methods Patients with PIH and normal pregnant woman were studied.5 HT and 5 HIAA in plasma from all subjects were measured with high performance liquid chromatography and electrochemical detection. Results There was no difference with 5 HT in plasma in three trimesters( P > 0.05 ).The concentration of 5 HT in plasma of PIH group(70 44±28 69 μg/L) was higher than that in normal group(24 96±6 57 μg/L)( P <0.01).The concentration of 5 HIAA in plasma of PIH group(4 11±2.30 μg/L) was less than that in normal group(7 87±1.75μg/L)( P <0.01). Conclusion 5 HT in plasma is related to the blood pressure of pregnancy woman;5 HT in plasma may take part in the pathophysiologic changes of PIH.
出处
《中华围产医学杂志》
CAS
1999年第1期6-7,共2页
Chinese Journal of Perinatal Medicine
关键词
妊娠高血压
综合征
血清素
羟基吲哚乙酸
病理
Pregnancy complications,cardiovascular Hypertension serotonin Hydroxyindoleacetic acid
