摘要
目的：为探讨胎盘５－羟色胺（５－ＨＴ）及其受体的含量与妊高征发病的关系。方法：应用免疫组织化学法和原位定量分析法，对１５例妊高征患者（ＰＩＨ组）和５例正常分娩的妇女（对照组）胎盘绒毛的５－ＨＴ及其受体进行检测。结果：对照组胎盘绒毛合体滋养层细胞及毛细血管内皮细胞的５－ＨＴ及５－ＨＴ受体免疫反应呈强阳性，妊高征组的胎盘绒毛合体滋养层细胞及毛细血管内皮细胞的５－ＨＴ及５－ＨＴ受体呈免疫反应弱阳性或阴性。原位定量分析结果显示，对照组胎盘绒毛合体滋养层细胞单位面积的５－ＨＴ及５－ＨＴ受体相对含量均高于妊高征组，两组比较，差异有极显著性（Ｐ＜０．００１）。结论：胎盘绒毛的５－ＨＴ及其受体的含量与妊高征的发病机理可能有密切关系。
Objective: To supply evidence of relationship between pregnancy induced hypertension (PIH) and 5 hydroxytryptamine (5 HT) and 5 hydroxytryptamine receptor (5 HTR) synthesized by placental villi. Methods: Five normal placentas and 15 placentas of PIH were used for studying localization and quantification of 5 HT and 5 HTR in placental villi by using immunohistochemical and in situ quantitative methods. Results: Syncytiotrophoblasts and capillary endothelium in placental villi of control group showed 5 HT and 5 HTR positive immunoreaction, but in placental villi of group with PIH, syncytiotrophoblasts appeared 5 HT and 5 HTR weak positive immunoreaction and capillary endothelim appeared 5 HT and 5 HTR weak positive or negative immunoreaction. The results of in situ quantitation showed that the content of 5 HT and 5 HTR in placental villus syncytiotrophoblasts of group with PIH were significantly lower than those in the control group. Conclusions: The content of 5 HT and its receptor in placenta may be related to PIH.
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
1997年第8期480-482,共3页
Chinese Journal of Obstetrics and Gynecology
关键词
妊娠高血压
综合征
受体
血清素
胎盘
5-HT
Pregnancy complications, cardiovascular Hypertension Serotonin Receptors, serotonin Placenta
