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效应性/调节性CD4＋T细胞失衡与慢性乙型肝炎

Imbalance of effective/regulatory CD4^＋T cell and chronic hepatitis B
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摘要 CD4＋T细胞是机体内一群重要的T细胞,在调节机体免疫中起关键作用.近年来研究发现,CD4＋T细胞可随机体状态、局部微环境的改变等分化为多种不同的亚群,除了传统的Th1和Th2细胞亚群之外.调节性T细胞、Th17等细胞亚群也相继被发现,从而发挥不同的功能.随着对效应性/调节性CD4＋T细胞研究的深入,人们发现其与慢性乙型肝炎的免疫耐受以及肝脏损伤机制密切相关.此文就效应性/调节性CD4＋T细胞的相互关系及其与乙型肝炎发病机制、抗HBV治疗的关系进行了综述. CD4^＋T cell plays an important role in immuno-regulatory.Recent studies have revealed that it could be differentiated into several different subtypes with the change of local micro-environment,such as Th1,Th2,T regula-tory cell,Th17 cell and so on.Imbalance of effective/regulatory CD4^＋T cell might be closely related to the pathogenesis of immunity resistance and liver injury in patients with chronic hepatitis B.In this article,the interactive relations of effective/regulatory CD4＋ T cell and mechanisms of hepatitis B onset and anti-viral treatment are reviewed.
作者 邢同京 徐洪涛
机构地区 江苏省泰州市人民医院感染病科
出处 《国际流行病学传染病学杂志》 CAS 2010年第2期129-132,共4页 International Journal of Epidemiology and Infectious Disease
关键词 肝炎 乙型 慢性 CD4+T细胞 发病机制 Hepatitis B,chronic CD4^＋ T cell Pathogenesis
分类号 R512.62 [医药卫生—内科学]
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参考文献31

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国际流行病学传染病学杂志
2010年 第2期

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