摘要
乙型肝炎病毒(HBV)感染呈世界流行趋势,是一个全球关注的健康问题,HBV作为一种非侵袭性嗜肝病毒,感染人体后并不直接损害肝脏,而是由其表达的抗原系统及其抗体所介导的特异性免疫反应和非特异性的以细胞因子为主的炎性介质导致的肝细胞损伤。特异性细胞免疫是清除机体内病毒的重要因素,针对HBV各类抗原表位的特异性细胞毒T淋巴细胞(CTL)作为主要的效应细胞,与病毒清除和细胞损伤有关,是当前研究的热点。本文就近年乙型肝炎病毒感染者特异性细胞免疫的研究现状作一综述。
Infection of Hepatitis B Virus（HBV）is presenting a popular trend in worldwild and has become a globle attention health problem.As a noninvasive eosinophilic liver virus,HBV doesn＇t directly damage the liver after infecting the body.The liver injury is resulted from the specific immune response induced by expression of antigen and antibody system and inflammations mainly mediated by non-specific cytokines.The specific cellular immune is the important factor in clearing virus.As chief effective cells,specific CTLs aimed at all kinds of epitopes are concerned with virus removing and cell damage.It is a hot spot on this field of research at present.This review article is a subjective passage for current state on hepatitis B virus in specific cellular immunity in recent years.
出处
《南通大学学报（医学版）》
2012年第1期54-57,共4页
Journal of Nantong University(Medical sciences)
