摘要
目的:比较在龈下刮治的同时使用不同的药物冲洗对慢性牙周炎患者龈沟液中II型胶原酶水平的影响。方法:选取90例慢性牙周炎患者,随机分为3组,在超声龈下刮治同时分别使用0.2%氯已定溶液、0.2%替硝唑溶液和生理盐水进行冲洗。收集治疗前及治疗2周后患牙的龈沟液并记录相关的临床指标。采用双抗体夹心ELISA法对龈沟液中II型胶原酶水平进行检测。结果:经过超声龈下刮治,患牙牙周临床指标均有明显的改善,龈沟液中II型胶原酶的水平明显降低,0.2%氯已定组和0.2%替硝唑组降低较生理盐水组更显著(P<0.01),但前两组之间无显著性差异(P>0.05)。结论:超声龈下刮治的同时使用抗菌药物冲洗会对龈沟液中II型胶原酶水平产生显著影响。
Objective To compare if simultaneous subgingival irrigation with different drugs during ultrasonic scaling could affect the II type Collagenase（COL-II）level in the Gingival Crevicular F1uid（GCF）of teeth with chronic periodontitis.Methods 90 patients with chronic periodontitis were selected and randomly divided into three groups.All patients were treated by ultrasonic scaling and irrigated respectively with 0.2%Chlorhexidine,0.2%Tinidazole and 0.9%Sodium Chloride at the same time.GCF was sampled and the periodontal indexes were recorded before treatment and two weeks after scaling.The COL-II level in GCF was detected using ELISA method.Results Two weeks after ultrasonic scaling,both periodontal indexes and the COL-II level in GCF reduced,and that in 0.2%Chlorhexidine,0.2%Tinidazole were significant lower than that in 0.9%Sodium Chloride（P0.01）.But no significant difference between the first two Groups（P0.05）.Conclusion Subgingival irrigation with 0.2%Chlorhexidine and 0.2%Tinidazole combining with ultrasonic scaling were more effective in reducing the COL-II level in GCF.
出处
《中国美容医学》
CAS
2010年第4期563-565,共3页
Chinese Journal of Aesthetic Medicine
关键词
龈沟液
龈下冲洗
II型胶原酶
氯已定
替硝唑
Gingival Crevicular Fl uid（GCF）
subgingival irrigation
Ⅱtype collagenase
Chlorhexidine
Tinidazole
