摘要
目的探讨宫颈局部应用红色诺卡氏菌细胞壁骨架制剂（Nocardia Rubra Cell Wall Skeleton，Nr-CWS）治疗人乳头状瘤病毒（hu-manpilloma avirus，HPV）感染的临床疗效。方法采用双盲随机对照试验设计，将感染HPV患者随机分配入2个组，实验组30例，安慰剂组10例，分别使用Nr-CWS和赋形剂。在治疗前、治疗后4133，治疗后8m共3次均于月经干净后3—10d对患者进行HPV检测，分析Nr-CWS对生殖道HPV感染的清除效果。结果4m后HPV检测示治疗组HPV感染转阴率为53．33％，与对照组（20％）比较，差异具有统计学意义（P〈0．05）。8m后HPV检测示治疗组HPV感染转阴率为70％，与对照组（30％）比较，差异具有统计学意义（P〈0．05）。结论Nr-CWS对女性下生殖道HPV感染有一定的清除作用。
Objective To investigate the clinical efficacy of nocardia rubra cell skeleton （Nr-CWS） preparation in treating cervical human papilloma virus （HPV） infection. Methods Patients with HPV were double-blind randomly divided into 2 groups： treatment group （treated with Nr-CWS for 1 course, n = 30） and control group （treated with the excipient of Nr-CWS, n = 10）. HPV detection was made 4 m before and after treatment, and 8 m after treatment. The elimination effect of Nr-CWS on HPV in genital tract was analyzed. Results The negative conversion rate of HPV infection in the treatment group was 53.33% 4 m after the treatment, was significantly higher than 20% in the control group （P 〈 0.05 ）. The negative conversion rate of HPV infection in the treatment group was 70% 8 m after the treatment, was significantly higher than 30% in the control group （P 〈 0.05 ）. Conclusion Clinical application of Nr- CWS can eliminate the HPV infection in lower genital tract of women with HPV infection.
出处
《今日药学》
CAS
2010年第4期6-9,共4页
Pharmacy Today
基金
广东省医院药学研究基金(编号:2009B007)
关键词
红色诺卡氏菌细胞壁骨架
人乳头瘤病毒
疗效
nocardia rubra cell skeleton
human papilloma virus
therapeutic effect
