摘要
卵巢恶性肿瘤的病因是多元的,病理学机制复杂。流行病学研究以及临床研究证实,炎症尤其是慢性炎症具有致癌作用。侵入肿瘤微环境的炎性细胞主要是肿瘤相关巨噬细胞(TAMs),在肿瘤发生、生长、侵袭和转移中起着重要作用。TAMs的致瘤作用包括表达生长因子、基质蛋白酶,促进血管生成、基质重塑以及抑制获得性免疫。研究TAMs在肿瘤的功能状态和动态变化有重要意义,TAMs有望成为治疗恶性肿瘤的潜在靶点。
Ovarian malignant tumors,nowadays,are still the focus of research for the multiple pathogenesis and complicated pathological mechanisms.Epidemical and clinical studies have confirmed that chronic inflammation contributes to cancer progression.Tumor-associated macrophages（TAMs）which represent a prominent component of the mononuclear leukocyte population that infiltrate in the tumor microenvironment play an indispensable role in tumorigenesis,growth,invasion,and metastasis.TAMs have several oncogenic functions,including expression growth factor and matrix proteases; promotion angiogenesis and matrix remodeling; suppression adaptive immunity.It′s significant to study the functional status and dynamic variation of TAMs which possess the potential target for future therapeutic approaches.
出处
《医学综述》
2010年第9期1333-1335,共3页
Medical Recapitulate
关键词
肿瘤相关巨噬细胞
炎症
卵巢恶性肿瘤
治疗
Tumor-associated macrophages
Inflammation
Ovarian malignant tumors
Therapeutic approaches
