摘要
目的:探讨胺碘酮(AM)对ST段抬高性急性心肌梗死(STEAMI)溶栓术后心肌缺血-再灌注损伤(MI/RI)的保护作用。方法:80例STEAMI溶栓患者随机分为A组(AM组,40例)和B组(对照组,40例),观察两组患者再灌注心律失常、二重乘积(SBP×HR)、CK-MB、cTnT、SOD、MDA的变化。结果:溶栓术后A组较B组再灌注心律失常明显减少,CK-MB、cTnT活性显著降低,MDA含量明显降低,SOD活性明显增高,差异有统计学意义(P<0.05);SBP×HR差异无统计学意义(P>0.05)。结论:应用AM对STEAMI溶栓患者MI/RI具有保护作用。
Objective： To investigate the protection of Amiodarone on myocardial ischemical reperfusion injury （MI/RI） of patients after thrombolysis of STEAMI. Methods： 80 patients with STEAMI, who were received thrombolysis, were randomly divided into two groups. Group A had 40 patients, were given Amiodarone; group B had 40 patients, were not given Amiodarone. The indexes of reperfusion arrhythmia, SBP×HR, CK-MB, cTnT, MDA and SOD of MI/RI in both groups were observed. Results： Compared with group B after thrombolysis, the reperfusion arrhythmia of group A was decreased, the activities of CK-MB and cTnT were decreased, MDA level was decreased, and the activity of SOD was increased, they showed statistical significance （P〈0.05）,; SBP×HR showed no statistical significance between the two groups （P〉0.05）. Conclusion： Amiodarone can relieve MI/RI on patients with STEAMI after thrombolysis.
出处
《中国医药导报》
CAS
2010年第13期17-18,21,共3页
China Medical Herald
