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子宫内膜癌中SFRP1基因启动子甲基化及其mRNA表达 被引量：1

Methylation of SFRP1 gene promoter and its mRNA expression in endometrial carcinoma
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摘要 目的研究子宫内膜癌中SFRP1基因启动子甲基化及其对SFRP1 mRNA表达的影响。方法应用甲基化特异性PCR技术检测36例子宫内膜癌组织和对应癌旁组织中SFRP1基因启动子甲基化状态,RT-PCR方法检测上述样本的mRNA表达水平,并对结果进行统计学分析。结果子宫内膜癌组织中SFRP1基因启动子甲基化的阳性率为47.2%,癌旁组织中为11.1%,两者比较差异有统计学意义(P=0.001)。14例存在启动子甲基化和5例无启动子甲基化的子宫内膜癌组织中缺乏SFRP1 mRNA表达或表达较癌旁组织明显下降。结论SFRP1基因启动子甲基化在子宫内膜癌中常见,部分成为其表达下降的原因。
作者 黄启成 陆锦标 汤春晖
机构地区 南通大学附属医院妇产科 南通大学医学院病理解剖学教研室
出处 《第二军医大学学报》 CAS CSCD 北大核心 2010年第4期450-452,共3页 Academic Journal of Second Military Medical University
关键词 子宫内膜肿瘤 SFRP1基因 DNA甲基化
分类号 R737.33 [医药卫生—肿瘤]
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参考文献10

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同被引文献9

  • 1YUKIO SONODA. Surgical treatment for apparent early stage endometrial cancer[J]. Obstet Gynecol Sci, 2014, 57(1): 1-10.
  • 2VISNOVSKY J, FIOLKA R, KUDELA E, et al. Hypermethylation of selected genes in endometrial carcinogenesis[J]. Neuroendocrinology Letters, 2013, 34(7): 675-680.
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  • 4OZTURK E, DIKENSOY E, BALAT O, et al. Association of en- dothelial nitric oxide synthase gent polymorphisms with endome- trial carcinoma: a preliminary study[J]. Journal of the Turk- ish-German Gynecological Association, 2011, 12(4): 229-233.
  • 5ZHU H, WU K, YAN W, et al. Epigenetic silencing of DACH1 induces loss of transforming growth factor-β1 antiproliferative re- sponse in human hepatocellular carcinoma[J]. Hepatology, 2013, 58(6): 2012-2022.
  • 6LEE JW, KIM HS, KIM S, et al. DACH1 regulates cell cycle progression of myeloid cells through the control of eyelin D, Cdk 4/6 and p21Cipl[J]. Biochemical and biophysical Research Com- munications, 2012, 420(1): 91-95.
  • 7GOKSEDEF B PC, AKBAYIR O, CORBACIOGLU A, et al. Comparison of preoperative endometrial biopsy grade and final pathologic diagnosis in patients with endometrioid endometrial cancer[J]. Journal of the Turkish-German Gynecological Associ- ation, 2012, 13(2): 106-110.
  • 8周定心,刘尚勤.DACH1在肿瘤细胞中的作用机制探讨[J].中国当代医药,2013,20(4):26-27. 被引量：2
  • 9符策岗,汪磊,宋银宏.抑癌基因甲基化与宫颈癌的关系[J].生命科学,2013,25(1):63-67. 被引量：8

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第二军医大学学报
2010年 第4期

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