摘要
目的观察不同病程的乙肝患者血清中ANA的表达及其与肝功能、HBVDNA的关系。方法对35例乙肝携带1患者、192例慢性乙肝患者,35例乙肝肝硬化患者检测血清中的ANA、肝功能、HBVDNA,并进行统计学分析。结果1.ANA在乙肝携带、慢性乙肝及乙肝肝硬化患者的血清中呈进行性升高趋势。2.192例患者中ANA阳性者共29例占15.10%,29例ANA阳性患者的ALT、TBil、ALB及HBVDNA较163例ANA阴性患者的均有升高,两者间差异有统计学意义(P<0.05)。结论ANA与乙肝患者的病程相关,并与HBVDNA复制水平及肝功能损伤的程度相关。
Objective To study the relationship between serum antinuclear antibody （ANA）,liver function tests and HBVDNA during the different course of hepatitis B virus （HBV） infection.Methods 35 HBV carriers,192 chronic hepatitis B （CHB） and 35 post-hepatitis B cirrhosis patients were included in the study.The ANA,liver function tests,and HBVDNA were measured.Results ANA was gradually increased in HBV carriers,chronic hepatitis B and cirrhosis patients.From 192 CHB patients,29 （15.1%） were ANA positive.The levels of ALT,TB,ALB and HBVDNA were significantly higher in ANA positives than ANA negative patients （P0.05）.Conclusion The serum level of ANA is correlated with disease course,HBVDNA replication and the degree of liver damage.
出处
《临床肝胆病杂志》
CAS
2010年第2期189-190,193,共3页
Journal of Clinical Hepatology
关键词
抗核抗体
乙肝
HBVDNA
肝功能
anti-nuclear antibodies
hepatitis B
HBVDNA
liver function test
