摘要
目的观察胃痛消痞方加减对功能性消化不良(FD)大鼠血清一氧化氮(NO)、血浆胃泌素(GAS)的影响。方法将50只大鼠以食醋灌胃建立FD模型,随机分为模型组,中药低、中、高剂量组,吗丁啉组。分别用生理盐水、不同浓度的胃痛消痞方加减、吗丁啉,每日2次灌胃治疗14d;观测各组大鼠血清NO、血浆GAS的含量。结果与模型组比较,各浓度胃痛消痞方加减均能明显降低NO含量、提高GAS含量,差异有统计学意义(P<0.01);中、高剂量组NO含量低于吗丁啉组(P<0.05);中药各剂量组GAS含量高于吗丁啉组(P<0.01),以中药中剂量组含量最高(P<0.01)。结论胃痛消痞方加减能通过降低血清中NO水平、提高血浆GAS水平,促进FD大鼠的胃肠动力。
Objective To observe the change of Weitongxiaopi Decoction on serum Nitric Oxide（NO）and plasma Gastrin（GAS）in functional dyspepsia（FD）rats.Methods To establish 50 models of FD rats by using vinegar,then the rats were randomly divided into 5 groups：model group,the change of Weitongxiaopi（WTXP）low dose group,middle dose group,large dose group and domperidone group.Different drugs were given to five groups：normal sodium,different concentrations of the change of WTXP Decoction and Domperidone twice a day by gastrogavage for 14 days[The content of the NO and GAS were observed.Results Different concentrations of the change of WTXP Decoction can all decrease serum NO,increase plasma GAS（compared with the model group,P0.01）[and the NO of middle and large dose groups were lower than that of domperidone group（P0.05）[GAS in every group of the change of WTXP Decoction was higher than that of domperidone group（P0.01）,in which,the middle group was higher than the other two groups（P0.01）.Conclusion The change of WTXP Decoction can promote the gastrointestinal motility of FD rats by means of decreasing the serum NO and increasing the plasma GAS.
出处
《实用药物与临床》
CAS
2010年第2期86-88,共3页
Practical Pharmacy and Clinical Remedies
基金
辽宁省科技厅自然科学基金(20082101)
