摘要
目的观察替加色罗在治疗反流性食管炎(RE)的疗效。方法80例患者随机分为两组,治疗组45例,替加色罗6 mg餐前半小时口服2次/d;对照组35例,多潘立酮(吗丁啉)10 mg餐前半小时口服3次/d;两组均加用雷贝拉唑20 mg,口服1次/d。治疗前后分别记录症状,同时检查血、尿、粪常规及培养,肝、肾功能。结果治疗组45例治疗有效率为86.7%;内镜下有效率为82.3%;对照组35例临床有效率为71.8%;内镜下有效率为65.7%;两组比较差异有显著性(P<0.05)。反流性食管炎的主要症状胸痛、胃灼热及反酸都明显改善,有效率分别为88.9%,85.3%,82.9%。替加色罗治疗期间发生腹泻3例。结论替加色罗联合雷贝拉唑治疗反流性食管炎具有良好的疗效。
Objective To observe the efficacy and safety of combined therany of tegaserod and raberprazole on reflux esophagitis. Methods All the 80 cases of reflux esophagitis were divided into two groups at random. Among the 80 cases, 45 were treated with tegaserod as treatment group, and 35 with domperidone as control group. Both the two groups were given raberprazole. The symptoms of reflux esophagitis were recorded. Blood, urine, stool, liver and renal functions were examined before and after the treatment. Results The effective rate of the treatment group was 85.7% （ improvement in 40 cases）, and it was 82.3% under endoscope, while the effective rate of the control group was 71.8%, with an effective rate of 65.7% under endoscope. The major symptoms of reflux esophagitis were burning pain, heartburn and reflux, which were ameliorated markedly respectively in 88.9%, 85. 3% and 82.9% of the cases. The difference in the efficacy between the two groups was statistically significant （P 〈 0.05）. Three cases of the treatment group suffered from diarrhea during the treatment. Conclusion The efficacy of combined therapy with tegaserod and raberprazole on reflux esophagitis is better than that of domperidone plus raberprazole.
出处
《临床军医杂志》
CAS
2005年第6期678-680,共3页
Clinical Journal of Medical Officers
