摘要
背景:人工肝血浆置换目前普遍应用于临床,给重型肝炎患者的治疗提供了新的手段。但是不同材料制备的膜型血浆分离器由于膜面积和孔径等存在差异,治疗效果也不尽相同。目的:观察由乙烯、乙烯醇共聚物制备的新型膜型血浆分离器Evacure-4A(EC-4A)治疗重型肝炎的临床疗效,并与由聚乙烯磺基制备的PS-06膜型血浆分离器进行对比分析。方法:65例重型肝炎患者在常规治疗基础上加用血浆置换治疗,其中治疗组35例应用新型膜型血浆分离器EC-4A,对照组30例应用PS-06膜型血浆分离器。检测治疗前后肝功能、肾功能、血电解质及血氨指标。结果与结论:PS-06对照组和Evacure-4A治疗组患者经血浆置换治疗后肝肾功能各指标均有明显好转,其中治疗组在治疗后的总胆红素、谷丙转氨酶、凝血酶原时间的改善程度和血清白蛋白的上升幅度以及血氨清除水平高于对照组(P<0.05),差异有显著性意义。结果提示Evacure-4A膜型血浆分离器治疗重型肝炎更安全有效。
BACKGROUND：The artificial liver plasmapheresis provides a novel method for severe hepatitis patients in clinic.However,the discrepancy of membrane plasma separator result in varied therapeutic efficacy.OBJECTIVE：To observe the therapeutic efficacy of the new type of membrane plasma separator Evacure-4A prepared by ethylene vinyl alcohol copolymer on severe hepatitis patients,in addition,to compare the results versus that of PS-06 membrane plasma separator.METHODS：Totally 65 severe hepatitis patients were given similar basic medical treatment and plasma exchange.In the treatment group（n=35）,patients were received plasma exchange using Evacure-4A membrane plasma separator,and those in the control group（n=30）,were using PS-06 membrane plasma separator.The hepatic function,renal function,blood biochemistry and blood ammonia were tested before and after the treatment.RESULTS AND CONCLUSION：Evacure-4A and PS-06 membrane plasma separators could both efficiently improve the hepatic function and renal function.The improvement of total bilirubin,alanine aminotransferase,prothrombin time,the increasing level of serum albumin and decreasing of blood ammonia in the treatment group were better than the control group（P 0.05）,there was obviously statistical significance.It is available and safe using the Evacure-4A membrane plasma separator to treat severe hepatitis.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第12期2249-2252,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
