摘要
目的 观察两种不同材料制备的膜型血浆分离器Evacure-4A与PS-06进行血浆置换治疗重型肝炎的疗效。方法 63例患者在内科综合治疗基础上联合血浆置换治疗,其中应用Evacure-4A膜型血浆分离器28例(A组),应用PS-06膜型血浆分离器35例(B组),检测治疗前、后肝功能。结果 经单次血浆置换治疗后,两组患者的总胆红素及直接胆红素明显降低,A组患者分别下降(41.6±10.6)％和(42.1±11.9)％,B组患者分别下降(42.1±11.9)％和(43.4±8.3)％,两组比较t值分别为0.98和0.7 3,P值均>0.05;两组患者血清白蛋白水平均有轻度升高,A组血清白蛋白上升幅度大于B组,A组为(8.3±10.7)％,B组为(3.4±9.3)％,t=2.76,P<0.01。结论 膜型血浆分离器Evacurc-4A可以减少白蛋白丢失,优于膜型血浆分离器PS-06。
Objective In order to compare the efficacy of two kinds of membrane plasma separator on the treatment of patients with severe hepatitis B. Methods 63 cases suffering from chronic severe hepatitis B were divided into two groups, 25 cases were treated with plasma exchange using Evacure-4A membrane plasma separator (A group) or 38 cases were using PS-06 membrane plasma separator (B group). Both of them also were treated with similar basic medical treatment. The level of serum total bilirubin, non-conjugated bilirubin, prothrombin time and albumin were tested at baseline and the end of the treatment with PE. Results Evacure-4A and PS-06 membrane plasma separators can effientively remove bilirubin, the levels of serum total bilirubin, non-conjugated bilirubin of all patients were significantly decreased after treated with PE. In A group, the level of serum total bilirubin, non-conjugated bilirubin decreased from (464.2 ± 193.8) umol/L to (279.4 ± 158.7) umol/L, (293.5 ± 129.1) μmol/L to (175.5 ± 106.7) μmol/L (t = 5.45, 10.36, P < 0.01) respectively. In B group, the level of serum total bilirubin, non-conjugated bilirubin decreased from (493.2 ± 126.9) umol/L to (299.7 ± 96.5) umol/L, (300.2 ± 74.3) umol/L to (171.5 ± 53.1) umol/L (t = 5.17, 12.04, P <0.01) respectively. The level of serum albumin increased after treated with PE in A and B groups, to contrast with PS-06, the increasing percentage of albumin was higher when the patients were treated with PE using Evacure-4A membrane plasma separator [(8.3 ± 0.7) % vs (3.4 ± 9.3) %, t = 2.76, P < 0.01]. Conclusion Evacure-4A membrane plasma separator may be better than PS-06 membrane plasma separator on the treatment of patients with chronic severe hepatitis B.
出处
《中华肝脏病杂志》
CAS
CSCD
2004年第4期208-209,共2页
Chinese Journal of Hepatology
