摘要
目的探讨缺血性心肌病患者的心率变异性变化。方法记录和分析60例缺血性心肌病患者的心率变异性时域参数平均正常RR间期标准差(sDNN)、每5min正常RR间期平均值标准差(sDANN)、相邻RR间期差的均方根(sMSSD)、相邻RR间期≥50 ms的百分数(pNN50)和频域参数极低频成分(vLF)、低频成分(LF)、高频成分(HF)和低频与高频比值(LF/HF),并与30例正常对照组进行对比分析。结果缺血性心肌病组时域参数sDNN、sDANN、rMSSD及pNN50均较对照组减低(P<0.05),频域参数vLF、LF和HF较对照组减低(P<0.05),LF/HF较对照组升高(P<0.05)。且心功能分级越高,上述变化越显著(P<0.05)。结论缺血性心肌病患者HRV明显减低,自主神经功能损害,以迷走神经功能的损害更为明显,且HRV指标的变化程度与心功能相关。
Objective To investigate and analyze the heart rate variability（HRV） in patients with ischemic cardiomyopathy.Methods The HRV of 60 patients with ischemic cardiomyopathy and 30 normal control subjects were investigated and analyzed.Results Time domain parameters including the 24-h SD of normal RR intervals（sDNN,ms）,the 24-h SD of 5-min average of normal RR intervals（sDANN,ms）,the square root of the mean of the squared differences between adjacent normal RR intervals（rMSSD,ms）.Comparing with control group,the proportion of successive RR intervals difference〉50 ms in %（pNN50） were significantly decreased in patients with ischemic cardiomyopathy（P〈0.05）.In frequency-domain parameters,the very low frequency（vLF） band,low frequency（LF） band,and,especially,high frequency（HF） band were remarkably lower（P〈0.05）,while the ratio of LF band to HF band（LF/HF ratio） significantly higher（P〈0.05）,in patients with ischemic cardiomyopathy than those in normal control group.Patients with higher New York Heart Association（NYHA） class had a lower sDNN,sDANN,rMSSD,pNN50,vLF band,LF band,and HF BAND but higher LF/HF ratio（P〈0.05）.Conclusion The HRV is significantly decreased,and is associated with heart function in patients with ischemic cardiomyopathy.Autonomic regulatory function is impaired,especially vagal function.
出处
《宁夏医学杂志》
CAS
2010年第4期337-338,共2页
Ningxia Medical Journal
关键词
缺血性心肌病
心率变异性
自主神经
Ischemic cardiomyopathy
Heart rate variability（HRV）
Autonomic nerve
