摘要
目的探讨人乳头瘤病毒（HPV）在宫颈炎、宫颈癌前病变、宫颈癌中的检测及意义。方法应用Hybrimax基因芯片导流杂交技术,对2008年1月-2009年1月在新疆医科大学附属肿瘤医院病房及门诊就诊的437例女性的宫颈细胞标本进行HPV基因型分型检测,比较慢性宫颈炎及不同宫颈病变组HPV感染的比例并进行分析。结果HPV总阳性率为41.19%。慢性宫颈炎HPV感染率为15.51%,宫颈癌前病变（CINⅠ＋Ⅱ＋Ⅲ）HPV感染率为54.71%和宫颈癌HPV感染率为64.52%,3组差异具有统计学意义（P〈0.05）。本组资料中单一感染比率为36.61%,最常见类型为HPV16和HPV31。多重感染的比例为11.11%,最常见类型为HPV16、58及HPV16、18二重感染。结论HPV感染是宫颈癌前病变和宫颈癌的主要致病因素;HPV16与宫颈癌密切相关;宫颈各病变中HPV感染以单一感染为主;高危型HPV持续感染是宫颈癌及癌前病变发生发展的必要条件。
Objective To investigate the detection and significance of the human papillomavirus（HPV） in chronic cervicitis,cervical intreapithelial neoplasia and cervical carcinaoma.Methods Cervical cell of 437 patients in our hospital were tested for genotypes HPV by flow-through hybridization and gene chip（HybriMax）.Results The positive result was 41.19%.15.51% HPV positive for cronic cervicitis,54.71% for cervical intraepithelial neoplasia,64.52% for cervical carcinoma;The HPV positive single infection result was 36.61%,the most common were HPV16 and HPV31,and multiple infection result was 11.11%,the most common were HPV16＋58 and HPV16＋18.Conclusion The infection of HPV is the main major etiological factor of chronic cervicitis,cervical intraepithelial neoplasia and cervical carcinaoma,especially HPV16;The high risk HPV is the main facter of cervical intreapithelial neoplasia and cervical carcinaoma.
出处
《新疆医科大学学报》
CAS
2010年第2期160-162,共3页
Journal of Xinjiang Medical University
关键词
人乳头状瘤病毒
慢性宫颈炎
宫颈上皮内瘤病变
宫颈癌
基因芯片导流杂交
human papillomavirus（HPV）
chronic cervicitis
cervical intreapithelial neoplasia
cervical carcinaoma
flow-through hybridization and gene chip
