摘要
为探讨依那普利、硝苯吡啶和洛伐他丁对高胆固醇兔动脉粥样硬化的影响，本文将３７只新西兰雄性白兔随机分为正常饮食组、胆固醇组、依那普利组、硝苯吡啶组和洛伐他丁组，后三组在高胆固醇饮食的基础上给相应药物。喂养１６周后处死所有动物，测定主动脉组织中胆固醇含量及斑块面积比。结果发现，依那普利和硝苯吡啶不影响血脂水平，洛伐他丁有降低胆固醇、甘油三脂及低密度脂蛋白的作用，洛伐他丁组低密度脂蛋白／高密度脂蛋白的比值明显低于胆固醇组、依那普利组和硝苯吡啶组。各组主动脉组织中胆固醇含量分别为１．０６±０．１６、４．９５±１．１９、２．５７±０．６２、３．４２±０．９０、３．１２±０．５２ｍｇ／ｇ主动脉湿重；斑块面积百分比分别为０、３８．９３％±７．９７％、１９．９８％±４．４２％、２７．７９％±８．２８％、１８．９４％±６．７５％；依那普利、硝苯吡啶和洛伐他丁三组的斑块面积均较胆固醇组明显减少（Ｐ＜０．０１）。结果提示，洛伐他丁能抑制高胆固醇血症，防止粥样斑块的形成，而依那普利和硝苯吡啶不影响高脂血症，却能保护动脉壁，预防和减轻粥样斑块的形成，它们抗动脉粥样硬化的途径是各不相同的。
Aim To investigate enalapril, nifedipine and lovastatin had the effects on experimental atherosclerosis in cholesterol rabbits. Methods Thirty seven rabbits were divide into five groups accidentally. Group A received normal chow, group B received cholesterol, group C received cholesterol plus enalapril, group D received cholesterol plus nifedipine and group E received cholesterol plus lovastatin. All rabbits were fed for sixteen weeks. At the end of the study, all animals were killed to determine the aortas cholesterol concentration and the percentage of aortic lesions covering the intimal surface. Results Enalapril and nifedipine didn't affect lipid level. Lovastatin reduced total cholesterol, triglyceride, and LDL level. The LDL/HDL ratio was less in lovastatin group than that in cholesterol, enalapril, and nifedipinegroups. The aortas cholesterol concentration and the plaque square in all drug groups were lower than in cholesterolgroup (P<0.05). Conclusion These three drugs had the effects of prophylaxis in experimental atherosclerosis.
出处
《中国动脉硬化杂志》
CAS
CSCD
1999年第1期44-47,共4页
Chinese Journal of Arteriosclerosis
关键词
动脉粥样硬化
依那普利
硝苯吡啶
洛伐他汀
Atherosclerosis
Model, Cardiovascular
Calcium Channel Blockers
Enalapril
Nifedipine
Lovastatin
Angiotensin Converting Enzyme Inhibitors
Hydroxymethylglutaryl CoA Reductases
Rabbits
