摘要
目的采用ＩＬ２ＰＥ４０、ＣｓＡ、雷公藤对角膜移植排斥反应进行实验性治疗。方法以Ｗｉｓｔａｒ大鼠异种角膜异位移植为模型，比较ＩＬ２ＰＥ４０、ＣｓＡ、雷公藤的免疫抑制疗效，同时测外周血Ｔ淋巴细胞亚群及Ｔ淋巴细胞集落形成数。结果ＩＬ２ＰＥ４０、ＣｓＡ、雷公藤均可推迟排斥反应的发生时间。ＩＬ２ＰＥ４０能明显减弱Ｔ淋巴细胞集落形成能力，Ｔ细胞集落数术前为２０１±１８．９，术后第５天为２１３±１９．４，而ＣｓＡ、雷公藤无该方面作用。结论ＩＬ２ＰＥ４０较ＣｓＡ、雷公藤特异性高，且提示有可能在更高层次上抑制排斥反应的发生。
ObjectiveIL 2 PE40,CsA and triperygium wilfordii hook were used to treat corneal allograft rejection.MethodsUsing the Wistar rat model of heterograft heterotopic graft rejection,40 rats were divided randomly into IL 2 PE40,CsA,triperygium wilfordii hook and the control group.On 2,5,7,10and 14d after the transplantation,the transplanted corneas were removed for pathological examination.The peripheral blood was collected for the analysis of T cell subgroups and T lymphocyte forming unit(T CFU)assay.ResultsIL 2 PE40,CsA and triperygium wilfordii hook can delay the development of corneal graft rejection and significantly reduce the percentage of T helper cells.IL 2 PE40 can weaken the gathering capacity of the peripheral T cell.ConclusionIL 2 PE40 has much more specific effect than other treatments and may inhibit the corneal rejection at higher levels.
出处
《眼科研究》
CSCD
1998年第4期251-253,共3页
Chinese Ophthalmic Research
基金
国家863攻关课题
