摘要
以间接免疫荧光技术对１６例蚕蚀性角膜溃疡患者血清抗兔、人角膜上皮细胞抗体及外周血Ｔ淋巴细胞亚群进行检测。结果表明：蚕蚀性角膜溃疡患者血清抗兔角膜上皮细胞抗体阳性率为７５％，抗人角膜上皮细胞抗体阳性率为３７．５％，２０例正常对照组均为阴性；患者组外周血Ｔ淋巴细胞亚群中，ＯＫＴ细胞百分值明显低于对照组（Ｐ＜０．０１），ＯＫＴ／ＯＫＴ细胞比值明显高于对照组（ｐ＜０．０１）。并讨论了本病的发病机理，指出患者免疫系统存在着免疫平衡调节紊乱，蚕蚀性角膜溃疡是自身免疫性眼病。
AbstractWith the indirect immuno fluorescence technique(IFT),the authors examined sera from 16 patientswith M ooren's ulcer for the presence of antibodiesagainst normal rabbit and human corneal epithelialcells,and determined the percentages of peripheralT-lymphocyte subsets in the patients and 20 controls.The results indicated that(1) antibodies against rabbitcorneal epithelial cells were positive in 75% of the pa-tients,and antibodies against human corneal epithelialcells were positive in 37.5%,whereas both antibodieswere negative in the controls,and(2) the percentage ofOKT in patients was significantly lower,and theOKT/OKT ratio significantly higher than in thecontrols.The authors concluded that regulatoryimbalance existed in the immune system of thepatients,and Mooren's ulcer was an autoimmunologiceye disease.
出处
《中华眼科杂志》
CAS
CSCD
北大核心
1994年第1期4-7,T004,共5页
Chinese Journal of Ophthalmology
