摘要
目的：为了探讨肝硬化和消化性溃疡患者血管活性肠肽（VIP）的变化及其调节机制。方法：测定了20例肝硬化和20例消化性溃疡患者的血浆VIP水平。结果：肝硬化[（140．25±28．23）ng／L]和消化性溃疡[（118．50±26．26）ng／L]患者的血浆VIP水平均昆著高于20例健康对照组[（1030±19．56）ng／L]，P分别＜0．001和＜0．05。肝硬化并发食管静脉曲张者显著高于无食管静脉曲张者[（153．18±23.69）ng／L与（124.44±26.15）ng／L，P＜0．02]，肝硬化有腹水者也高于无腹水者[（158．88±22．23）ng／L与（129．17±27．12）ng／L，P＜0.05]。肝硬化患者血浆VIP浓度与凝血酶原时间呈正相关（r=0．68、P＜0．01），与血清白蛋白浓度呈负相关（r=-0．59，P＜0．01）。胃溃疡和十二指肠溃疡患者血浆VIP水平无显著差异[（114．50±24．55）ng／L与（122．50±28．60）ng／L，P＞0．05]。结论：这些患者的血浆VIP水平升高可能与VIP分泌增加、肝脏灭活减少、清除降低和（或）存在门体分流有关。
Objective:To investigate the changes of vasoactive intestinal peptide(VIP) in patients with hepatic cirrhosis and peptic ulcer and its regulating mechanism. Methods:Plasma VIP levels in 20 patients with hepatic cirrhosis and 20 with peptic ulcer were measured.Rcsult:The levels of VIP in patients with hepatic cirrhosis (140.25 ± 28.23)ng / L and peptic ulcer (118.50±26.26)ng / L were significantly higher than those in 20 healthy control subjects (103.0 ± 19.56)ng / L, P < 0.001 and P < 0.05,respectively. The levels of VIP in caesc of hepatic cirrhosis complicated with esophageal varices were significantly higher than those without esophageal varices (153. 18 ± 23.69)ng / L vs;(124.44 ± 26. 15)ng / L, P < 0.02) and the levels of VIP in patients associated with ascites were also higher than those without (158.88 ± 22.23)ng / L vs, (129. 17 ± 27. 12)ng / L, P < 0.05. Plasma VIP levels in patients with hepatic cirrhosis were positively correlated with prothrombin time (r= 0.68,P < 0.01), and negatively correlated with albnmin (r= -0.59, P < 0.01). There was no difference of plasma VIP levels between the patients with gastric ulcer and those with duodenal ulcer (114.50 ± 24.55)ng / L vs.(122.50 ± 28.60)ng / L, P > 0.05).Conclusion:Incrcased secretion of VIP, impaired inactivation of VIP in the cirrhotic liver, decreased clearance of VIP and / or the presence of portosystemic shunt may contribute to the high plasma levels of VIP in these patients.
出处
《广西医科大学学报》
CAS
1998年第4期29-30,共2页
Journal of Guangxi Medical University
关键词
肝硬化
消化性溃疡
血管活性肠肽
hepatic cirrhosis
peptic ulcer
vasoactive intestinal peptide
