摘要
探讨血管活性肠肽 (VIP)对肝硬化患者食管动力的影响。方法 对 35例肝硬化患者 (HC)和 30名健康人 (HS)采用放射免疫法 (RIA)测定血浆VIP含量 ;采用核素法测定食管液体通过时间和胃食管反流。结果 HC组血浆VIP含量显著高于HS组 (P <0 .0 1) ;HC组胃食管反流发生率显著高于HS组 ;HC组中胃食管反流患者的VIP含量显著高于无胃食管反流的患者 (P <0 .0 1) ,HC组的食管液体通过时间较HS组显著延长 (P <0 .0 1) ,但VIP含量与食管通过时间无相关性 (P >0 .0 5 )。结论 肝硬化患者血浆VIP含量的升高可能使食管下端括约肌 (LES)松弛而产生胃食管反流 。
Objective To explore the effect of VIP on the esophageal motility in patients with hepatic cirrhosis(HC).Methods Esophageal liquid transit time and gastroesophageal reflux with scintigraphy, and plasma VIP concentration with radioimmunoassay(RIA) were detected in 35 patients with HC and 30 healthy subjects(HS).Results There was significant difference in plasma VIP concentration were between HC group and HS group ( P <0.01); the frequency of gastroesophageal reflux in HC group was markedly higher than that in HS group; there was also significant difference in plasma VIP concentration between patients without and with gastroesophageal reflux ( P <0.01); the esophageal liquid transit time was markedly prolonged in HC group as compared with HS group, but there was no correlation between VIP concentration and esophageal transit time. Conclusion VIP may influence lower esophageal sphincter and cause gastroesophageal reflux, but has little effect on esophageal peristalsis.
出处
《肝脏》
2000年第2期95-96,共2页
Chinese Hepatology
关键词
血管活性肠肽
肝硬化
食管动力学
LES
Vasoactive intestinal peptide
Cirrhosis
Radioimmunoassay
Scintigraphy
Esophageal motility
