摘要
采用放射免疫测定法研究了肝硬化（ＨＣ）患者血浆及胃粘膜内血管活性肠肽（ＶＩＰ）和生长抑素（ＳＳ）含量变化及其意义。结果表明：肝硬化患者血浆和胃粘膜内的ＶＩＰ含量和ＳＳ含量均显著高于正常对照组（Ｐ＜０．０１）；ＨＣ伴溃疡病患者血浆及胃粘膜中ＳＳ含量显著高于无溃疡的ＨＣ患者（Ｐ＜０．０５）；血浆及胃粘膜中ＶＩＰ的含量随着胃、十二指肠粘膜充血程度的加剧而升高；并且血浆及胃粘膜内ＶＩＰ和ＳＳ含量与肝功能密切相关。提示：在ＨＣ时存在着严重的胃肠激素代谢率乱，并且它在ＨＣ的病理生理机制和ＨＣ时胃肠功能改变和病理变化中起着重要作用。
The contents of vasoactive intestinal peptide(VIP) and somatostatin(SS) in palsma and gastric mucosa in patients with hepatic cirrhosis(HC) were tested by redioimmunoassay. The results showed that the contents of VIP and SS in patients with HC were significantly higher than in normal subjects(P<0.01);the contents of SS in cases of HC with peptic ulcer were sinificantly higher than that without peptic ulcer(P<0.05).A positive correlation was noted between contents of VIP and the degree of con- gestion of gastroduodeual mucosa(P<0.05) and esophageal varices(P<0.05).There was a negative corre-lation between contents of VIP,SS and albnmin(P<0.01)and a positive correlation between contents of VIP,SS and prothrombin time(P<0.01),The results suggest that there was severe disorder of gastrointestinal hormones in patients with HC.
出处
《肝脏病杂志》
CSCD
1995年第3期152-154,共3页
