摘要
目的研究芸香苷(Rutoside,Ru)对大鼠急性胰腺炎(Acute Pancreatitis,AP)胰腺毛细血管通透性的影响。方法wistar大鼠48只,随机分为6组,每组8只,分别建立大鼠假手术(SO)、急性胰腺炎(AP)、芸香苷(Ru)高、中、低剂量及丹参(DS)组,在制模后3、6h经下腔静脉取血,测定血清淀粉酶含量和磷脂酶A2活性。切取胰腺标本组织,对胰腺组织进行病理检查和胰腺微血管通透性测定。结果术后6h,各组大鼠胰腺毛细血管通透性分别为:SO组(89.10±26.02)、AP组(405.25±234.48)、Ru高剂量组(132.79±56.72)、Ru中剂量组(203.83±89.06)、Ru低剂量组(263.84±113.02)、DS组(191.22±77.05)。各组间比较,6hRu高剂量和中剂量组胰腺毛细血管通透性低于AP组(P<0.01)。结论Ru能明显降低AP大鼠胰腺毛细血管通透性,减轻胰腺组织病理性损害。
Objective To study the effect of rutoside （Ru） on pancreatic capillary permeability in rats with acute pancreatitis （AP）. Methods Forty-eight Wistar rats were randomly divided into sham operation group, AP group, high-, middle-, low-dosage Ru groups, and Dan shen （Radix Salviae Militorrhize） group （n=8）. Three and six hours after establishment of the models, serum amylase level and PLA2 activity were measured in blood samples taken from inferior vena cava of rats, and pancreatic tissue samples were used to determine the capillary permeability and pathology of the pancreas. Results Six hours after establishment of the models, the pancreatic capillary permeability was 89.10±26.02mg/g, 405.25±234.48mg/g, 132.79±56.72mg/g, 203.83±89.06mg/g, 263.84±113.02mg/g, and 191.22±77.05mg/g, respectively, in the 6 groups, while the pancreatic capillary permeability was lower in the high-and middle-dosage Ru groups than in the AP group （P0.01）. Conclusion Ru can significantly reduce the pancreatic capillary permeability in rats with AP and improve their pancreatic lesions.
出处
《军医进修学院学报》
CAS
2010年第4期358-359,362,共3页
Academic Journal of Pla Postgraduate Medical School
基金
安徽省科技厅自然科学基金(01043907)
安徽省教育厅自然科学基金(2001kj122)~~
