摘要
目的探讨葡萄球菌蛋白A免疫吸附治疗高群体反应性抗体肾移植受者的临床疗效。方法采用蛋白A免疫吸附柱对5例高群体反应性抗体(PRA)肾移植受者进行免疫吸附治疗,共治疗21次,治疗后择期进行肾移植。结果4例患者肾移植前伴有高水平PRA的患者,蛋白A免疫吸附治疗后血清PRA和IgG、IgM水平明显下降,肾移植术后未发生急性或超急性排异反应;1例伴有高水平PRA、肾移植术后发生急性排异反应的患者,蛋白A免疫吸附治疗后血清PRA和免疫球蛋白水平明显下降,急性排异反应迅速缓解。结论蛋白A免疫吸附能有效降低患者血清群体反应性抗体水平,防治肾移植术后排斥反应。
Objective To study the clinical effect of Staphylococcal protein A （SPA） immunoadsorption in renal transplant recipients with high panel reactive （anti HLA） antibodies. Methods Five renal transplant recipients with high anti HLA antibodies were treated 21 times with immunoadsorption column （Wuhan Paisheng）, and then underwent kidney transplantation. Results The levels of serum panel reactive antibody （PRA）, IgG and IgM were significantly decreased in 4 renal transplant recipients with high panel reactive （anti HLA） antibodies after treatment, with no acute or hyper-acute rejection occurred. Acute rejection occurred in 1 renal transplant recipient with a high PRA level. However, the serum levels of PRA and immunoglobin were remarkably reduced and acute rejection was alleviated in this patient after treatment. Conclusion Protein A immunoadsorption can effectively decrease the high serum PRA level in renal transplant recipients, and can thus be used in prevention and treatment of rejection after kidney transplantation.
出处
《军医进修学院学报》
CAS
2010年第4期329-330,共2页
Academic Journal of Pla Postgraduate Medical School
关键词
免疫吸附技术
群体反应性抗体
肾移植
Immunosorbent Techniques
Panel Reactive （anti HLA） Antibody
Kidney Transplantation
