摘要
目的:了解肾移植受者的HLA体液致敏状态,筛选合适供者及通过PRA变化早期诊断急性排斥。方法:通过微量补体依赖淋巴细胞毒试验检测269例患者的群体反应性抗体(PRA)。结果:肾移植受者中PRA阳性受者移植后排斥反应发生率明显高于非致敏受者(P<0.001),移植后PRA水平升高组的排斥发生率显著高于PRA无变化组(P<0.001)。结论:PRA是预测受者致敏状态的一个敏感指标,对临床筛选合适供者,减少排斥反应,提高移植物存活率及早期诊断排斥具有重要意义。
Objective To evaluate the HLA sensitivity status and the HLA antibody specificity of the renal transplant recipients to select the appropriate donors and to early diagnose hyper-acute rejection through variety of panel reactive antibody （PRA）. Methods With the use of grouped lymphocytes tray, PRA level of 269 patients was measured by the micro-complement-dependent-lymphocyto-toxicity test. Results The incidence of rejection after transplantation was obviously higher in the PRA positive recipients （P 〈 0. 001 ）. Much higher rejection rate were nwas in recipience with high PRA level after transplantation. Conclusion The PRA determinations is a sensitive factor predicting the sensitivity status of the recipients and plays a significant role in the selection of appropriate donors so as to achieve a decline of rejection rate and the increase of graft survival rate and early diagnose hyper-acute rejection.
出处
《实用医学杂志》
CAS
2005年第17期1881-1882,共2页
The Journal of Practical Medicine
