摘要
目的探讨免疫吸附对高致敏肾移植受者超急性排斥反应的预防作用。方法对10例群体反应抗体(PRA)>40%的肾移植受者术前行免疫吸附治疗,观察其超急性排斥反应发生情况及不良反应。结果10例高致敏肾移植受者均未发生超急性排斥反应,仅有2例发生急性排斥反应,并通过免疫吸附及调整免疫抑制剂得到逆转。所有受者随访至今移植肾功能良好,未发生排斥反应。结论免疫吸附可以安全、有效地预防高致敏人群肾移植术后超急性排斥反应。
Objective To investigate immunoadsorption in the prevention ot hyperacute rejection in highly sensitized recipients of renal allografts. Methods Immunoadsorption treatment was performed on 10 patients whose panel reactive antigen （PRA） was more than 40%. The adverse effect and hyperacute rejection were observed. Results Two cases of acute rejection of renal allografts were found in highly sensitized recipients and reversed by the therapy of immunoadsorption and adjusting immuno-suppressive drugs. Conclusion Immunoadsorption treatment could effectively and safely pre vent highly sensitized recipients from hyperacute rejection post-transplantation.
出处
《中华器官移植杂志》
CAS
CSCD
北大核心
2006年第4期213-214,共2页
Chinese Journal of Organ Transplantation
关键词
免疫吸附技术
肾移植
移植物排斥
Immunosorbent techniques
Kidney transplantation
Graft rejection
