摘要
为观察人参二醇组皂甙（ＰＤＳ）对体外循环（ＣＰＢ）手术病人的心肌保护作用，将６０例ＣＰＢ手术病人，随机均分为对照组与ＰＤＳ组。ＰＤＳ组术前２天和术前３０分钟，按１５ｍｇ／ｋｇ，共３次，静脉滴注ＰＤＳ。测定两组ＣＰＢ期间（转流前、转流１５、３０分钟、再灌注１５、３０、６０分钟）血清超氧化物歧化酶（ＳＯＤ）和丙二醛（ＭＤＡ）含量。结果发现ＣＰＢ时间与ＳＯＤ活性成反比，与ＭＤＡ含量成正比。两组ＳＯＤ活性总均数ＰＤＳ组较对照组高，差异显著（Ｐ＜０．０１）；两组ＭＤＡ含量总均数ＰＤＳ组较对照组低，差异有显著性（Ｐ＜０．０１）。结论：术前应用ＰＤＳ可显著提高ＣＢＰ手术病人ＳＯＤ活性，减少ＭＤＡ生成，从而防治心肌再灌注损伤。
Aim:This study was conducted to evaluate the myocardial protective effects of panaxadiol saponins(PDS)on patients during cardiopulmonary bypass(CPB).Clinical material and method:Sixth patients with congenital heart disease underwent surgical repair under CPB.There were 25 boys and 35 girls with a mean age of 7.8 years.The mean body weight was 20.5kg with a range of 15 to 35kg.The patients were randomly divided into two groups.Control group(n=30)received no medications before surgery.PDS group received 15μg/kg PDS intravenously two days and 30 minutes before surgery.The blood samples were taken at six different time intervals for assessing the levels of superoxide dismutase(SOD)and malondialdehyde(MDA).The mean CPB time was 50 minutes.Results:In control group,the level of SOD gradually increased and MDA decreased with increased time of CPB.Both SOD and MDA reached their peak value at 30 minutes after reperfusion.When compared with control group,the SOD level were significantly higher while MDA were significantly lower in PDS group.Conclusion:This study suggest that preoperative treatment with PDS can reduce myocardial ischemic and reperfusion injuries.
出处
《中华胸心血管外科杂志》
CSCD
北大核心
1998年第6期366-368,共3页
Chinese Journal of Thoracic and Cardiovascular Surgery
基金
吉林省卫生厅基金
关键词
人参二醇组皂甙
体外循环
心肌保护
Panaxadiol saponins Cardiopulmonary bypass Superoxide dismutase Malondialdehyde Reperfusion injury
