摘要
将１，４－二（苯并唑－１，３－基－２）苯（ＢＢＯＢ）包埋在增塑的聚氯乙烯膜中，研制了一种新的荧光猝灭型甲硝唑光纤传感器．猝灭机制包括甲硝唑的初级内滤效应和甲硝唑与ＢＢＯＢ形成电荷转移复合物两种作用．传感器可逆性好，响应时间小于３０ｓ，响应线性范围是４．００×１０－６～１．００×１０－４ｍｏｌ／Ｌ，检测限为１．００×１０－６ｍｏｌ／Ｌ，对１．００×１０－４ｍｏｌ／Ｌ甲硝唑的相对偏差为０．８２％（ｎ＝１０）．常见的无机离子、药物不影响甲硝唑的测定，对商品制剂中甲硝唑的测定结果与药典法一致．
A fluorophore of 1,4 bis(1,3 benzoxazol 2 yl)benzene(BBOB) was selected as sensing molecule for constructing a new metronidazole optic fiber sensor. The sensing performence is based on the fluorescence quenching of the plasticized PVC optode membrane trapped with BBOB by metronidazole. The quenching mechanism includes a primary inner filter effect and the formation of a charge transfer complex between BBOB and metronidazole extracted from aqueous phase into membrane phase. In the range of 4.00×10 -6 ￣1.00×10 -4 mol/L, the sensor responds linearly to metronidazole with a detection limit of 1.0×10 -6 mol/L metronidazole. A good reversibility and a rapid response within 30 s were obtained. The relative standard deviation of repeating measurements of 1.00×10 -4 mol/L metronidazole is 0.82%( n =10). The sensor shows good selectivity over the common inorganic ions and pharmaceutical species and therefore can be used for the direct determination of metronidazole in commercial preparations, the results were in agreement with those obtained by pharmacopoeia method.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1998年第9期1383-1387,共5页
Chemical Journal of Chinese Universities
基金
国家教育委员会博士点(批准号:9553201)基金
机械工业部技术发展基金
