摘要
目的：研究氯化镁缓释片的释放度和相对生物利用度。方法：采用原子吸收分光光度法测定氯化镁缓释片和进口氯化镁缓释片（ＳｌｏｗＭａｇ）的体内外释放浓度，计算体内外参数，考察氯化镁缓释片的缓释效果，并与ＳｌｏｗＭａｇ进行对照。结果：氯化镁缓释片体外释放符合Ｈｉｇｕｃｈｉ模型；氯化镁缓释片和ＳｌｏｗＭａｇ的药时曲线可用二室模型拟合，ｔｍａｘ分别为３７９６７ｈ和２１３６７ｈ，ｃｍａｘ分别为７８２５７μｇ·ｍｌ－１和８０２５４μｇ·ｍｌ－１，ＡＵＣ分别为５６５１７２，３４１９７１μｇ·ｈ·ｍｌ－１。结论：氯化镁缓释片对ＳｌｏｗＭａｇ的相对生物利用度为１６５２６％。
OBJECTIVE:To study the release property and relative bioavailability of sustained release magnesium cholride tablet(MCST).METHODS:The magnesium concentrations were determined by AAS method.The parameters were calculated and the sustained release effect of MCST was inspected.RESULTS:The release rate of MCST was conformed to Higuchi equation,and the concentration time courves of MCST and Slow Mag were conformed to a two compartment model.The t max were3.7969 h and 2.1367 h,c max 7.8257μg·ml -1 and 8.0254μg·ml -1 ,AUC 56.5172,34.1971 μg·h ml -1 respectively.CONCLUSION:The relative bioavailability of MCST was 165.26%,and the two formulations were not bioequivalent.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1998年第12期738-740,共3页
Chinese Pharmaceutical Journal
关键词
氯化镁
缓释片
分光光度法
释放度
生物利用度
sustained release magnesium chloride tablet,AAS,release property,bioavailability
