摘要
多功能细胞因子干扰素(IFN)是生物细胞受到适量的干扰素诱生剂刺激后所产生的一类微量的、具有高度生物学活性的糖蛋白,具有广谱抗病毒、抗肿瘤、免疫调节及影响细胞分化等生物活性。与之相对应,抗IFN的单克隆抗体McAb作为一种重要的研究、检测IFN的手段,已被广泛应用于免疫机制研究、免疫功能检测、纯化IFN等领域。综述了各种IFN单克隆抗体、用途及其前景。
Interferons,a kind of multifunctional cytokines,are microcrystalline and high biologically active glycoproteins secreted by cells which were stimulated by interferon inducers.It has extensive anti-virus activity,anti-tumor activity and powerful immunoloregulation action.Correspondingly,as an important method of IFN investigation and detection,monoclonal anti-IFN antibodies have been applied to immunologic mechanism research,immunologic function detection,IFN purification and so on.The various kinds of IFN McAbs,application and prospect were summarized.
出处
《安徽农业科学》
CAS
北大核心
2010年第5期2241-2243,2260,共4页
Journal of Anhui Agricultural Sciences
基金
科技部质检公益项目
