摘要
目的 观察放射性^131I联合甲亢舒口服液治疗甲状腺功能亢进症（甲亢）的效果。方法465例甲亢患者，随机分为对照组235例，治疗组230例。对照组采用^131I治疗，治疗组在对照组的基础上加服甲亢舒口服液，观察两组疗效及治疗前后血清T3、T4、FT3、FT4、TSH水平变化。结果治疗组治疗后12个月的治愈率74．7％（172／230），高于对照组的65．1％（153／235）（χ2=3．94，P〈0．05）；治疗组总有效率88．6％，高于对照组的80．4％（χ2=3．90，P〈0．05）；两组治疗后12个月与治疗前比较，血清T3、T4、FT3、FT4水平明显下降，TSH水平上升（t=2．745、2．778、2．845、2．812、2．833，均P〈0．05），且治疗组治疗12个月后T4、FT3、FT4水平较对照组的下降更明显（t=2．145、2．178、2．245，均P〈0．05）；治疗组血清抗甲状腺球蛋白抗体、抗甲状腺微粒体抗体转阴率均显著高于对照组（r=3．98、3．88，均P〈0．05）。结论甲亢舒口服液联合^131I治疗甲亢效果显著。
Objective To observe the treatment efficacy in patients with hyperthyroidism by 131 radioactive iodine in conjunction with Jiakangshu oral solution. Methods 465 cases with hyperthyroidism were divided into control group（n = 235） and treatment group（ n = 230）. In tire treatment group on the basis of 131 iodine therapy plus service Jiakangshu oral sdution. Tire contents of T3 ,T4, FT3, FT4 ,TSH were observed before and ＇after treatment. Results Tbe cure rate 74. 7% in treatment group after treatment 12-month was higher than 65. 1% （χ2 = 3.94,P 〈 0. 05 ） ,total effective rate 88.6% was higher than 80. 4% （ χ2 = 3.90, P 〈 0. 05 ）. The contents of T3, T4, FT3, FT4 ,TSH drop, but TSH levels increased in two groups after 12 months with those before treatment（ t =2. 745,2. 778,2. 845,2. 812, 2. 833, all P 〈 0.05 ）. The contents of T3 , T4 , FT3, FT4 in treatment group decreased significantly compared with the control group after treatment 12 months （ t = 2. 145,2. 178,2. 245, all P 〈 0. 05 ）. The negative conversion rate of TGAb, TMAb in the treatment group were significantly higher than control group （ χ2 = 3. 98,3. 88, all P 〈 0. 05 ）. Conclusion The treatment effecs are obvious in patients with hyperthyroidism by 131 radioactive iodine in conjunction with JiaKangShu oral solution.
出处
《中国基层医药》
CAS
2010年第2期154-155,共2页
Chinese Journal of Primary Medicine and Pharmacy
关键词
甲状腺功能亢进症
碘苷
甲亢舒
Hyperthyroidism
Idoxuridine
Jiakangshu oral solution
