摘要
目的:探讨131I联合小剂量地塞米松治疗早期甲状腺功能亢进症后对患者甲状腺功能的影响。方法:选择2012年5月—2015年5月孝感市中心医院收治的90例甲状腺功能亢进症患者,按随机数字表法分为观察组和对照组各45例。对照组应用小剂量地塞米松进行治疗,观察组在对照组基础上联合131I进行治疗,比较2组治疗前及治疗1个月后的总三碘甲状腺原氨酸(TT3)、血清总甲状腺素(TT4)、基础代谢率、并发症与不良反应发生情况。结果:2组治疗前TT3、TT4、基础代谢率的差异无统计学意义(P>0.05),治疗后,2组患者各项指标均有所改善,差异有统计学意义(P<0.05),同时观察组患者TT3、TT4低于对照组,基础代谢率高于对照组,差异有统计学意义(P<0.05),提示观察组各项指标改善幅度更大。2组并发症发生率均为11.1%(5/45);观察组患者不良反应发生率为17.8%(8/45)、对照组为15.6%(7/45),差异均无统计学意义(P>0.05)。结论:131I联合短期小剂量地塞米松治疗甲状腺功能亢进症可有效促进甲状腺功能的改善,效果佳,副作用少,为理想治疗方案。
OBJECTIVE：To probe into the effects of 131 I combined with low-dose dexamethasone on thyroid function in patients with early hyperthyroidism .METHODS： 90 patients with hyperthyroidism admitted into Central Hospital of Xiaogan from May 2012 to May 2015 were selected to be divided into observation group and control group via the random number table , with 45 cases in each .The control group were treated with low-dose dexamethasone , while the observation group additionally received 131 I based on the control group .Before treatment and after treatment of 1 month , total triiodothyronine （ TT3 ） , total serum thyroxine （ TT4 ） , basic metabolic rate , incidence of complications and adverse drug reactions were compared between two groups .RESULTS：Before treatment , there were no significant difference in TT 3 , TT4 and basic metabolic rate between two groups （ P 〉0.05 ） .After treatment , indicators of two groups had been improved , the before and after differences within groups were statistically significant （P〈0.05）.Besides, TT3 and TT4 of the observation group were lower than those of the control group while the basic metabolic rate was higher than that in the control group （ P〈0.05 ） , which indicated that the improvement of the indicators in the observation group were more significant .The incidence of complications in both of the two groups was 11.1%（5/45）.The incidence of adverse drug reactions of observation group was 17.8%（8/45）,the control group was 15.6% （ 7/45 ） , with no statistically significance （ P 〉0.05 ） .CONCLUSIONS： 131 I combined with low-dose dexamethasone in treatment of patients with early hyperthyroidism can improve the thyroid function , with few side effects, which is an ideal treatment scheme .
出处
《中国医院用药评价与分析》
2016年第6期770-772,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
