摘要
目的:评价应用脱矿冻干骨粉(decalcified freeze-dried bone allograft,DFDBA)植骨术以及脱矿冻干骨粉与富血小板血浆(platelet-rich plasma,PRP)联合植骨术治疗牙周骨下袋的临床疗效。方法:选择完成牙周基础治疗3个月的12例牙周炎患者(慢性牙周炎9例,侵袭性牙周炎3例)的15处骨下袋(30个位点),其中10处骨下袋(20位点)进行DFDBA植骨术(DFDBA组),另外5处(10个位点)进行DFDBA与PRP联合植骨术(DFDBA+PRP组),术后6个月复查,比较两组治疗前后的菌斑指数(plaque index,PI)、出血指数(bleeding index,BI)、牙周探诊深度(probing depth,PD)和临床附着丧失(clinical attachment loss,CAL),评价临床疗效,并比较两组植骨术的临床疗效差别。结果:DFDBA组术前的平均PI,BI,PD和CAL分别为1.7,2.7,6.0 mm和7.0 mm;术后6个月时分别为1.5,1.8,3.9 mm和4.4 mm。DFDBA+PRP组术前的平均PI,BI,PD和CAL分别为1.8,2.9,6.2 mm和7.1mm;术后6个月时分别为1.5,1.7,3.2 mm和3.6 mm。术后两组PI无明显变化,BI,PD和CAL均比术前明显减少(P<0.01),而DFDBA+PRP组PD和CAL的改善优于DFDBA组(P<0.05)。结论:DFDBA植骨术以及DFDBA与PRP联合植骨术治疗牙周骨下袋均有良好临床疗效,而后者的疗效更优于前者。
Objective：To evaluate the effect of decalcified freeze-dried bone allograft（DFDBA） and DFDBA with platelet-rich plasma（PRP） in the treatment of periodontal infrabony defects.Methods： Fifteen periodontal infrabony defects（30 sites） in 12 patients with periodontitis（9 patients with chronic periodontitis and 3 patients with aggressive periodontitis） were selected.Three months after initial therapy,they were assigned to either the DFDBA group（10 defects with 20 sites） or the DFDBA with PRP group（5 defects with 10 sites）.The patients were evaluated for plaque index（PI）,bleeding index（BI）,probing depths（PD） and clinical attachment loss（CAL） before the treatment and at 6 months after periodontal bone graft surgery.Results： The PI,BI,PD and CAL in the DFDBA group were 1.7,2.7,6.0 mm and 7.0 mm at baseline;1.5,1.8,3.9 mm and 4.4 mm at the 6 months after periodontal surgery.The PD,CAL and BI in DFDBA with PRP group at baseline were 6.2 mm,7.1 mm and 2.9;3.2 mm,3.6 mm and 1.7 at the 6 months after periodontal surgery.The PI did not change significantly after surgery in both groups.While both groups showed significant improvement（P〈0.01） in BI,PD and CAL,the improvement in the DFDBA with PRP group was significant greater than in the DFDBA group（P〈0.05）.Conclusion： DFDBA is an effective therapy for periodontal intrabony defects.DFDBA with PRP can significantly improve the clinical effect of periodontal infrabony defects.
出处
《北京大学学报（医学版）》
CAS
CSCD
北大核心
2010年第1期24-27,共4页
Journal of Peking University:Health Sciences
基金
首都医学发展科研基金(2005-2007)资助~~
关键词
牙周袋
血小板聚集
骨移植
移植
同种
Periodontal pocket
Platelet aggregation
Bone transplantation
Transplantation
homologous
