摘要
背景:实验发现,富血小板血浆+骨移植修复骨缺损,不仅使新骨形成速度快,而且成骨密度高。目的:观察自体富血小板血浆与自体骨移植治疗粉碎性骨折,观察其疗效。方法:临床随机对照前瞻性队列研究。选取四肢粉碎性骨折及骨缺损患者42例,随机分为2组:实验组20例采用自体富血小板血浆与自体髂骨松质骨混合,植于粉碎性骨折骨缺损处;对照组22例仅行钢板螺钉或髓内钉内固定。术后及治疗后1,3,6,12个月拍摄X射线片检查,比较两组愈合情况、愈合速度,以及功能恢复情况。结果与结论:骨折愈合时间,实验组平均12周,对照组18周,两者比较差异有显著性意义。对照组有2例发生钢板断裂,1例骨不连再次手术,3例骨折延迟愈合;实验组未出现自体输血及其他并发症。结果说明自体富血小板血浆与自体骨移植治疗粉碎性骨折可促进和加速骨愈合。
BACKGROUND： Studies showed that platelet-rich plasma ＋ bone transplantation for repair of bone defects not only can accelerate new bone formation, but also increase bone density. OBJECTIVE： To observe autologous platelet-rich plasma and autologous bone graft for treatment of comminuted fractures, and the efficacy. METHODS： This was a clinical prospective randomized controlled study. A total of 42 patients with limb comminuted fracture and bone defects were enrolled and randomly assigned to two groups. In the experimental group, 20 patients received treatment with autologous platelet-rich plasma and mixture of autologous ilium and cancellous bone. In the control group, 22 patients underwent plate, screw or intramedullary nail fixation. At 1, 3, 6 and 12 months after surgery, X-ray examination was conducted. Healing conditions, healing speed and functional recovery were compared between the experimental and control groups. RESULTS AND CONCLUSION： The time of bone healing was respectively 12 weeks in the experimental group and 18 weeks in the control group on average, showing significant differences. There were two cases of plate breakage, one case of nonunion reoperation, three cases of delayed fracture healing in the control group. No autologous blood transfusion or other complications appeared in the experimental group. Results suggested that autologous platelet-rich plasma and autologous bone graft for comminuted fractures can facilitate and accelerate bone healing.
出处
《中国组织工程研究》
CAS
CSCD
2014年第22期3603-3608,共6页
Chinese Journal of Tissue Engineering Research
基金
克拉玛依市级科研项目(ks2010-46)~~
