摘要
目的:总结中枢神经系统血管周细胞瘤(HPC)的研究进展。方法:应用Medline及CNKI期刊全文数据库检索系统检索1995-01-2008-02关于中枢神经系统HPC分子发病机制、临床病理特点及治疗方面的文献。选取21篇有代表性的与研究有关的文献进行分析。结果:中枢神经系统HPC是一种与脑膜相关的少见肿瘤,该肿瘤起源于毛细血管周围具有收缩功能的Zimmerman血管外皮细胞。组织学上具有特征性的鹿角状血管,丰富的网状纤维包绕肿瘤细胞,免疫组化表达Vim-entin、CD34和Bcl-2。它易复发和转移,手术切除是首选的治疗手段,术后放疗可降低复发率。结论:中枢神经系统HPC具有侵袭性,需要与其他肿瘤鉴别,确诊有赖于病理组织学和免疫组织化学等。长期随访是必要的。
OBJECTIVE：To review the recent advances in studies of hemangiopericytoma （HPC） in the central nervous system. METHODS：The data of HPC in the central nervous system were searched from 1995-01 to 2008-02 in Medline and CHKD. The literature that mainly included the molecular etiology,clinicopathologic studies,and therapeutics was screened. The 21 papers of representative focus literature were selected into the analysis. RESULTS：HPC in the central nervous system is rare and typically attached to the meninges,These tumors originate from contractile Zimmerman＇s pericytes around capillaries. The histological characteristics are ＂stag-horn＂ like vessels with abundant reticulin fibers surrounding the tumor cells. The immunohistochemical examination shows the tumor cells are stained for Vimentin,CD34 and Bcl-2. HPC in the central nervous system tends to recur and metastasize. The surgical management is the best choice for treatment of patients with HPCs. Postoperative radiotherapy can postopone the risk of tumor recurrence. CONCLUSIONS：HPCs are aggressive tumors and should be differentiated from other tumors in central nervous system. The final diagnosis of this tumor depends on histology and immunohistochemistry. The prolonged patient follow-up is advisable.
出处
《中华肿瘤防治杂志》
CAS
2009年第24期1970-1972,共3页
Chinese Journal of Cancer Prevention and Treatment
基金
国家自然科学基金(30700874)
