摘要
目的探讨颅内原发性血管周细胞瘤的临床病理特征、诊断与鉴别诊断,以更好地认识该种疾病。方法回顾性分析6例颅内血管周细胞瘤临床资料、病理组织学特点、免疫组化标记和网状纤维染色特点。结果颅内血管周细胞瘤由密集的大小一致的肿瘤细胞组成,无特定的排列方式,伴有少量纤维化。肿瘤含有大量裂隙状血管,血管腔隙呈＂鹿角状＂。免疫组化示肿瘤细胞vimentin和CD34均为（＋）,Ki-67增殖指数为5%~20%,EMA和PR均为（-）。网状纤维染色显示肿瘤细胞周围有丰富的网状纤维围绕。结论血管周细胞瘤由密集的细胞组成,其内血管呈＂鹿角状＂,免疫组化和网状纤维染色有助于诊断。
Objective To explore the clinicopathologic features, diagnosis and differential hcmangiopericytoma in the central nervous system, in order to improve recognition of this disease. Methods diagnosis of Six cases of hemangiopericytoma were retrospective analyzed by clinical features, clinicopathologic features, immunohistochemistry and reticular fiber staining. Results Hemangiopericytomas were monomorphous tumors composed of closely packed, randomly oriented tumour cells with little intervening fibrosis. Hemangiopericytoma was highly vascular, like ＂staghorn sinusoids＂. Immunohistochemistry showed that vimentin and CD34 were positive, and the positive rate of Ki-67 was 5% - 20%. EMA and PR were negative. Reticular fiber staining was positive, typically investing individual cells. Conclusion Hemangiopericytomas in the central nervous system are monomorphous tumors composed of closely packed cells, with ＂staghorn sinusoids＂ like structure. Immunohistochemical study using appropriate antibodies and reticular fiber staining play an important role in definitive diagnosis of hemangiopericytomas.
出处
《诊断病理学杂志》
CSCD
2015年第9期551-553,共3页
Chinese Journal of Diagnostic Pathology
