摘要
目的研究在中国北方汉族人群中抵抗素基因5’末端启动子区g-420 C>G多态性与高血压发病年龄的相关性。方法选取高血压病组121例,其中年龄<40岁的43例,年龄≥40岁的78例,对照组92例,其中年龄<40岁的42例,年龄≥40岁的50例,采用聚合酶链反应-限制性片长多态性方法分析抵抗素420 C/G多态性基因型。结果高血压病患者中,年轻患者的抵抗素基因420 G/G基因型频率高于年长组(P=0.006),其与发病年龄相关;年龄<40岁的年轻人群中,高血压病患者的抵抗素基因420 G/G基因型频率也显著高于对照组(P=0.001),其与高血压病发病相关。结论高血压病青年发病与抵抗素基因420 G/G基因型相关。
Aim To investigate the relation between the resistin gene 5＇promoter region-420 CG polymorphism and the age at onset of hypertension.Methods 121 hypertension were selected,including 43 age 40 years,78 age ≥ 40 years and 92 control,including 42 age 40 years,50 age ≥ 40 years,the resistin 420 C/G polymorphism genotype was analyzed by polymerase chain reaction-restriction fragment polymorphism（PCR-RFLP）.Results The frequency of the G/G genotype of resistin single nucleotide polymorphism at-420 in younger hypertension was higher（P=0.006）and related to the age of onset.In young group,the frequency of the G/G genotype in hypertension was higher than control（P=0.001）and related to the onset of hypertension.Conclusion Younger-onset hypertension was related to the G/G genotype of resistin single nucleotide polymorphism at-420.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2009年第12期1027-1029,共3页
Chinese Journal of Arteriosclerosis
