摘要
目的 :研究糖尿病、脑梗死以及急性心肌梗死患者血浆抵抗素水平的变化 ,探讨抵抗素在上述疾病过程中的病理生理意义。方法 :清晨空腹抽血 ,分离血浆 ,采用竞争性酶联免疫法检测血浆抵抗素含量。结果 :健康人血浆Resistin含量为 (36 4 6± 14 32 )ng/ml,不同性别间无明显差异。 2型糖尿病患者血浆抵抗素含量明显低于健康对照组 (16 36± 7 4 7)ng/mlvs (36 4 6± 14 32 )ng/ml,P <0 0 1。脑梗死患者血浆抵抗素水平亦明显低于正常对照组 (2 0 0 1± 10 5 5vs 36 4 6± 14 32ng/ml,P <0 0 1) ,而陈旧性脑梗死患者明显高于新发病患者 (31 2 5± 15 4 6 )vs (2 0 0 1± 10 5 5 )ng/ml,P <0 0 5。急性心肌梗死患者血浆抵抗素水平为 (12 18±3 87)ng/ml,明显低于健康人 (P <0 0 1) ,发病后第 5d和第 2d相比 ,血浆抵抗素水平无明显变化 (11 6 4±3 5 7)vs (11 98± 3 95 )ng/ml,P >0 0 5。结论 :2型糖尿病、脑梗死以及急性心肌梗死患者血浆抵抗素水平明显下降 ,提示抵抗素可能在心、脑血管疾病和糖尿病这些具有代谢综合征表现的疾病发展过程中发挥重要的调控作用。
Objective To investigate the significance of changes of plasma resistin levels in patients with non-insulin-dependent diabetes (NIDD), cerebral infarction (CI) and acute myocardial infarction (AMI). Methods Plasma resistin levels were measured with EIA in 26 patients with NIDD, 44 patients with CI, 21 patients with AMI and 32 controls. Results The plasma resistin levels in controls were 36.46±14.32ng/ml. There were no differences between males and females. The concentrations of plasma resistin were significantly lower in patients with NIDD than those in controls (16.36±7.47 ng/ml vs 36.46±14.32 ng/ml, P<0.01). In patients with CI, resistin levels were 20.01±10.55ng/ml, which were also signficiantly lower than those in controls (P<0.01). However, resistin levels in patients with old cerebral infarction were higher than those in acute patients. In patients with AMI, resistin level was 9.8±4.59ng/ml, being significantly lower than those in controls (P<0.01). Resistin levels on d2 and d5 after the event were about the same. Conclusion The plasma resistin levels in patients with NIDD, CI and AMI were decreased signficantly and the result suggested resistin that might play regulative roles in the development of these diseases which shared the common features of metabolic syndrome.
出处
《放射免疫学杂志》
CAS
2004年第5期400-403,共4页
Journal of Radioimmanology
基金
国家重点基础研究发展规划项目 ( 973 )基金 (G2 0 0 0 0 5 690 5 )资助
