摘要
目的 研究resistin在正常人、单纯性肥胖、糖尿病和甲状腺功能亢进 (甲亢 )病人血浆中的平均水平。方法 采用竞争性酶联免疫吸附试验测定血浆中resistin水平。结果 正常人群组中 ,resistin在不同年龄、不同性别组之间差异均无统计学意义 (P >0 .0 5 ) ,正常人群组resistin平均水平为 (2 0 .5± 2 8.5 )ng/ml;resistin水平与体重指数呈正相关 (P <0 .0 1) ,与抵抗指数呈负相关 (P <0 0 5 )。正常组与肥胖组 [(70 .9± 6 8.0 )ng/ml]、糖尿病组 [(16 4.4± 137.9)ng/ml]、甲亢组 [(15 7.6±142 8)ng/ml]之间的差异均具统计学意义 (P <0 .0 0 1) ,肥胖组与糖尿病组、甲亢组之间的差异也具统计学意义 (P <0 .0 0 2 ) ,糖尿病组与甲亢组之间的差异无统计学意义 (P >0 .5 )。结论 resistin在正常组、肥胖组、糖尿病组的水平有递增的趋势 ,并且resistin水平分别与体重指数和胰岛素抵抗指数呈正、负相关 ;
Objective To study and compare the level of resistin in healthy volunteers and patients with obesity, diabetes mellitus and hyperthyroidism. Methods A competitive ELISA was used to test resistin in plasma. Results No statistical difference was found among age groups and between male and female ( P >0.05). The mean level of healthy volunteers was [(20.5±28.5) ng/ml]. Resistin level showed a positive correlation with BMI ( P <0 01) and an inverse correlation with resistance index ( P <0.05). Resistin level in healthy volunteers had a statistical difference with that of patients with obesity [(70.9±68.0) ng/ml], diabetes mellitus [(164.4±137.9) ng/ml] and hyperthyroidism [(157.6±142.8) ng/ml] ( P <0.001). This was also found while comparing resistin level of patients with obesity with that of diabetes mellitus and hyperthyroidism ( P >0 002). But there was no difference between diabetes and hyperthyroidism ( P >0.5). Conclusions There is an increasing trend of resistin level in healthy volunteers and patients with obesity, diabetes mellitus and hyperthyroidism in order Resistin also was a positive and an inverse correlation with BMI and resistance index respectively. These results support the hypothesis of Steppan that resistin causes insulin resistance and links obesity to diabetes, and that the high level of resistin in hyperthyroidism can help to explain the phenomenon of its insulin resistance.
出处
《中华检验医学杂志》
CAS
CSCD
北大核心
2001年第6期359-361,共3页
Chinese Journal of Laboratory Medicine
基金
国家重点基础研究发展规划项目基金 (G2 0 0 0 0 5 6 90 5 )
