摘要
目的:探讨超促排卵周期胚胎移植日血清雌二醇(E2)浓度的变化对体外受精-胚胎移植(IVF-ET)治疗结局的影响,为制定个体化黄体支持方案提供参考。方法:回顾性分析125个IVF-ET周期,按ET日血清E2浓度变化分为4组:A组:24个治疗周期,ET日血清E2浓度/HCG注射日E2浓度<0.4;B组:54个周期,0.4≤ET日E2/HCG日E2<0.7;C组:32个周期,0.7≤ET日E2/HCG日E2<1;D组:15个周期,ET日E2/HCG日E2≥1。结果:C组胚胎种植率和妊娠率最高,A组种植率和妊娠率均显著降低(P<0.05)。结论:IVF-ET采用长方案控制性超排卵(COH),移植日E2水平过高或过低均影响治疗结局,监测E浓度对制定个体化黄体支持方案具有重要的临床价值。
Objective： To explore the effect of changes of serum estradiol concentration on the day of human ehorionie gonadotropin （HCG） administration in luteal phase on the outcomes of in vitro fertilization - embryo transfer （ IVF - ET）, provide reference for making individual corpus lutealum support scheme. Methods： 125 IVF -ET cycles were analyzed retrospectively, then divided into 4 groups according to changes of serum estradiol concentration on the day of HCG administration ： group A ： 24 cycles, the ratio of estradiol concentration on ET day/estradiol concentration on HCG day 〈 0. 4 ; group B ： 54 cycles, 0. 4 ≤ the ratio of estradiol concentration on ET day/estradiol concentration on HCG day 〈 0. 7 ; group C ： 32 cycles, 0. 7 ≤ the ratio of estradiol concentration on ET day/estradiol concentration on HCG day 〈 1 ; group D： 15 cycles, the ratio of estradiol concentration on ET day/estradiol concentration on HCG day≥1. Resets： The implantation rate and pregnancy rate in group C were the highest, and the implantation rate and pregnancy rate in group A decreased significantly （ P 〈 0. 05） . Conclusion： For the cases adopting long protocol of controlled ovarian hyperstimulation （COH） in IVF - ET, too high or two low estradiol concentration on ET day may affect the outcomes, monitoring estradiol concentration is of clinical value in making individual corpus luteum support scheme.
出处
《中国妇幼保健》
CAS
北大核心
2010年第6期818-820,共3页
Maternal and Child Health Care of China
关键词
体外受精-胚胎移植
雌二醇
黄体期
胚胎着床
In vitro fertilization -embryo transfer
Estradiol
Luteal phase
Embryo implantation
